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Role of Divalent Ions in Membrane Models of Polymyxin-Sensitive and Resistant Gram-Negative Bacteria.
J Chem Inf Model
January 2025
Central European Institute of Technology, Masaryk University, Brno60200, Czech Republic.
Polymyxins, critical last-resort antibiotics, impact the distribution of membrane-bound divalent cations in the outer membrane of Gram-negative bacteria. We employed atomistic molecular dynamics simulations to model the effect of displacing these ions. Two polymyxin-sensitive and two polymyxin-resistant models of the outer membrane of were investigated.
View Article and Find Full Text PDFThe nature of self-medication in Uganda: a systematic review and meta-analysis.
BMC Public Health
January 2025
Department of Microbiology and Immunology, Faculty of Biomedical Sciences, Kampala International University-Western Campus, Ishaka, Uganda.
Background: In Uganda, many people self-medicate and the practice raises important questions about access to healthcare, patient choices, and the increasing prevalence of antimicrobial resistance. This systematic review and meta-analysis investigated the prevalence and factors associated with self-medication in Uganda.
Methods: We searched Scopus, PubMed, and Embase databases, WHO AFRO, UNIPH registries, and Google Scholar search engine from inception to November 2024 using the algorithm "Self-Medication" AND "Uganda".
Periorificial dermatitis in infants and preschoolers - a narrative review.
Eur J Pediatr
January 2025
Department of Dermatology & Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany.
Periorifical dermatitis (POD) is a papular, chronic inflammatory skin disease commonly seen in women in their 2nd to 4th decade of life. The major differential diagnosis is persistent acne. In children, POD is less common than in adults.
View Article and Find Full Text PDFGerman evidence- and consensus-based guideline on the management of penile urethritis.
J Dtsch Dermatol Ges
January 2025
Department of Infection Epidemiology, Robert Koch Institute, Berlin, Germany.
Urethritis is a common condition predominantly caused by sexually transmitted pathogens such as Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium. It is not possible to differentiate with certainty between pathogens on the basis of clinical characteristics alone. However, empirical antibiotic therapy is often initiated in clinical practice.
View Article and Find Full Text PDFDifferences of microbial growth and biofilm formation among periprosthetic joint infection-causing species: an animal study.
Int Microbiol
January 2025
Department of Orthopedics and Traumatology, Ankara University School of Medicine, Ankara, Turkey.
Purpose: The most frequently used surgical procedures for periprosthetic joint infections (PJIs) are debridement, antibiotics, and implant retention (DAIR), as well as single- or two-stage revision arthroplasty. The choice of surgery is made depending on the full maturation of the biofilm layer. The purpose of this study was to evaluate the biofilm formation and microbial growth using common PJI-causing agents and compare its development on the implant surface.
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