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Treponematosis in critically endangered Western chimpanzees () in Senegal.
One Health
June 2024
IHU-Méditerranée Infection, Marseille, France.
Article Synopsis
- Treponematoses are chronic bacterial diseases primarily transmitted through sexual contact or direct interaction, but their epidemiology in wild primates remains largely unexplored due to the difficulty of studying these animals.
- This study focused on critically endangered Western chimpanzees in Senegal, using a non-invasive stool serology method that revealed anti-treponemal antibodies in 13 out of 29 chimpanzees tested.
- The findings highlight the importance of using non-invasive methods for disease surveillance in wildlife, emphasizing the need to assess and manage the risk of treponematosis within chimpanzee populations as part of a comprehensive One Health strategy.
Serosurvey of Treponema pallidum infection among children with skin ulcers in the Tarangire-Manyara ecosystem, northern Tanzania.
BMC Infect Dis
June 2020
Work Group Neglected Tropical Diseases, Infection Biology Unit, Deutsches Primatezentrum GmbH, Leibniz Institute for Primate Research, Kellnerweg 4, 37077, Goettingen, Germany.
Background: The first yaws eradication campaign reduced the prevalence of yaws by 95%. In recent years, however, yaws has reemerged and is currently subject to a second, ongoing eradication campaign. Yet, the epidemiological status of Tanzania and 75 other countries with a known history of human yaws is currently unknown.
View Article and Find Full Text PDFDual screen and confirm rapid test does not reduce overtreatment of syphilis in pregnant women living in a non-venereal treponematoses endemic region: a field evaluation among antenatal care attendees in Burkina Faso.
Sex Transm Infect
September 2019
Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Objectives: In resource-limited settings, screening pregnant women for syphilis using rapid diagnostic tests (RDTs) is a key tool in the prevention of congenital syphilis. However, most syphilis RDTs detect only treponemal antibodies (T-RDT), meaning antibiotics may be provided unnecessarily to previously treated pregnant women, particularly in non-venereal treponematoses endemic regions. We estimated the potential reduction in overtreatment when comparing T-RDT (SD Bioline) to a newer rapid test (Dual Path Platform (DPP) Screen and Confirm Assay, Chembio) detecting both treponemal and non-treponemal antibodies.
View Article and Find Full Text PDFPoint-of-care tests for syphilis and yaws in a low-income setting - A qualitative study of healthcare worker and patient experiences.
PLoS Negl Trop Dis
April 2018
Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.
Introduction: The human treponematoses comprise venereal syphilis and the three non-venereal or endemic treponematoses yaws, bejel, and pinta. Serological assays remain the most common diagnostic method for all treponemal infections. Point-of-care tests (POCTs) for syphilis and yaws allow testing without further development of infrastructure in populations where routine laboratory facilities are not available.
View Article and Find Full Text PDFBackground: Use of treponemal tests to screen for syphilis (caused by Treponema pallidum pallidum) poses challenges with infection status classification, especially in settings where other treponemal infections are endemic. This study aimed to determine the validity of the syphilis surveillance testing strategy implemented since 2004 using two treponemal tests, and estimate the seroprevalence of active syphilis infection in Ghana where yaws (caused by Treponema pallidum pertenue) is endemic.
Methods: We retested sera from the 2007 HIV sentinel survey (HSS) using a traditional algorithm, quantitative rapid plasma reagin test followed by qualitative Treponema pallidum haemagglutination assay.
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