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Effects of Globularia cordifolia on colon cancer cells: antioxidant activity, inflammatory cytokine analysis and molecular docking studies.
J Sci Food Agric
December 2024
Faculty of Veterinary Medicine Department of Biochemistry, Ondokuz Mayis University, Samsun, Turkey.
Background: The present study aimed to comprehensively evaluate the anticancer, anti-inflammatory, and antioxidant properties of Globularia cordifolia L.
Samples: The plant material was collected and extracted using the maceration method. Antioxidant activities were assessed through DPPH (i.
Antitumoral action of carvedilol-a repositioning study of the drug incorporated into mesoporous silica MCM-41.
Nanotechnology
November 2024
University of Franca; Av. Dr. Armando Salles Oliveira, 201, Pq. Universitário CEP 14404-600, Franca, SP, Brazil.
We have studied repositioning of carvedilol (an antihypertensive drug) incorporated into MCM-41 mesoporous silica. The repositioning proposes a reduction in the slow pace of discovery of new drugs, as well as toxicological safety and a significant reduction in high research costs, making it an attractive strategy for researchers and large pharmaceutical companies. We obtained MCM-41 bysynthesis and functionalized it by post-synthesis grafting with aminopropyltriethoxysilane (APTES) only or with folic acid (FA), which gave MCM-41-APTES and MCM-41-APTES-FA, respectively.
View Article and Find Full Text PDFSynthesis, Activity, Toxicity, and In Silico Studies of New Antimycobacterial -Alkyl Nitrobenzamides.
Pharmaceuticals (Basel)
May 2024
Research Institute for Medicines (iMed.UL), Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
Article Synopsis
- Tuberculosis (TB) is a serious disease affecting vulnerable populations, and researchers have created new compounds called -alkyl nitrobenzamides that show potential against TB by targeting the enzyme DprE1 found in Mycobacterium tuberculosis (Mtb).
- The study demonstrated that specific derivatives of these compounds, particularly those with certain chemical structures and chain lengths, exhibited strong antitubercular activity, performing similarly to the existing TB treatment, isoniazid.
- Evidence from docking studies suggests that these compounds likely work by interacting with the DprE1 enzyme, supporting their potential as viable candidates for TB therapy.
Effect of silver sulfadiazine on mature mixed bacterial biofilms on voice prostheses.
J Otolaryngol Head Neck Surg
November 2023
Department of Otolaryngology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1# ShuaiFuYuan, Dongcheng District, Beijing, 100730, People's Republic of China.
Background: Biofilm formation on voice prostheses disrupts the function and limits the lifespan of voice prostheses. There is still no effective clinical strategy for inhibiting or removing these biofilms. Silver sulfadiazine (SSD), as an exogenous antibacterial agent, has been widely used in the prevention and treatment of infection, however, its effect on voice prosthesis biofilms is unknown.
View Article and Find Full Text PDFLosartan Plays a Fungistatic and Fungicidal Activity Against Biofilms: Drug Repurposing for Localized Candidosis.
Assay Drug Dev Technol
June 2023
Immunopharmacology Laboratory, Department of Basic Sciences, São Paulo State University (UNESP), School of Dentistry. Araçatuba, Brazil.
Candidosis is one of the most frequent opportunistic infections and exhibits variable clinical presentations, including oral localized forms. Drugs affecting the renin-angiotensin system targets inhibit secreted aspartic proteases from . The objective of the study was to evaluate whether losartan has antimicrobial action against biofilms.
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