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Fast Quantum Control of Cavities Using an Improved Protocol without Coherent Errors.
Phys Rev Lett
December 2024
Yale University, Department of Applied Physics and Physics, New Haven, Connecticut 06511, USA.
The selective number-dependent arbitrary phase gates form a powerful class of quantum gates, imparting arbitrarily chosen phases to the Fock states of a cavity. However, for short pulses, coherent errors limit the performance. Here, we demonstrate in theory and experiment that such errors can be completely suppressed, provided that the pulse times exceed a specific limit.
View Article and Find Full Text PDFIntralesional injection of CpG ODNs complexed with glatiramer acetate mitigates systemic cytokine toxicities and synergistically advances checkpoint blockade efficacy.
Drug Deliv Transl Res
January 2025
Kinimmune, Inc. St. Louis, 63141, Missouri, USA.
PD-L1/PD-1 checkpoint inhibitors (CPIs) are mainstream agents for cancer immunotherapy, but the prognosis is unsatisfactory in solid tumor patients lacking preexisting T-cell reactivity. Adjunct therapy strategies including the intratumoral administration of immunostimulants aim to address this limitation. CpG oligodeoxynucleotides (ODNs), TLR9 agonists that can potentiate adaptive immunity, have been widely investigated to tackle PD-L1/PD-1 resistance, but clinical success has been hindered by inconsistent efficacy and immune-related toxicities caused by systemic exposure.
View Article and Find Full Text PDFA Novel Rabbit Model of Meibomian Gland Dysfunction-Induced Dry Eye.
Transl Vis Sci Technol
January 2025
Johnson & Johnson Vision Care, Inc., Jacksonville, FL, USA.
Purpose: The objective of this three-phase study was to develop a model of mild to moderate evaporative dry eye to be used to evaluate tear film stability endpoints during product development.
Methods: Rabbits were sedated prior to ophthalmic cautery of meibomian gland orifices. The orifices of eyelid meibomian glands were half-cauterized (to yield obstruction of every other meibomian gland orifices), fully cauterized (to yield obstruction of all meibomian gland orifices), or untreated.
Spermidine enhances the heat tolerance of by promoting mitochondrial respiration driven by fatty acid β-oxidation.
Appl Environ Microbiol
January 2025
Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Unlabelled: High temperature is an unavoidable environmental stress that generally exerts detrimental effects on organisms and has widespread effects on metabolism. Spermidine is an important member of the polyamines family and is involved in a range of abiotic stress responses in plants. Mitochondria play an essential role in cellular homeostasis and are key components of the stress response.
View Article and Find Full Text PDFDetermining the optimal antibiotic duration for skin and soft tissue infections.
Curr Opin Infect Dis
January 2025
Department of Medicine, Clínica Rotger Quironsalud, Palma de Mallorca, Spain.
Purpose Of Review: Optimal duration of therapy in SSTIs - a heterogeneous group of infections - remains unknown. The advances in knowledge of antibiotic duration of treatment in selected SSTIs that can impact clinical practice and published in the last 18 months are reviewed.
Recent Findings: Recent evidence indicates that few patients receive guideline concordant empiric antibiotics and appropriate duration in the United States, although this likely can be extrapolated to other countries.
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