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Healthy Lifestyle Changes Improve Cortisol Levels and Liver Steatosis in MASLD Patients: Results from a Randomized Clinical Trial.
Nutrients
December 2024
Scientific Direction, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, BA, Italy.
Steatotic liver disease associated with metabolic dysfunction (MASLD) affects up to about 30% of the general adult population and is closely related to obesity and the metabolic syndrome. Cortisol, a stress-related hormone contributing to hepatic fat accumulation and insulin resistance, also promotes progression of the disease. The study aims to investigate the impact of lifestyle modifications on cortisol levels and hepatic steatosis in patients with MASLD.
View Article and Find Full Text PDFEffect of Caloric Restriction and Aerobic Exercise on Premenstrual Syndrome, Anthropometric, and Hormonal Parameters in Obese Females: A Randomized Controlled Trial.
Physiother Res Int
January 2025
Department of Physical Therapy for Women's Health, Cairo University, Giza, Egypt.
Background And Purpose: Premenstrual syndrome (PMS) affects physical, psychological, and behavioral symptoms in women. Obesity may worsen PMS, but the impact of caloric restriction and aerobic exercise on PMS in obese women is unclear. This study examines their effects on PMS, anthropometric, and hormonal parameters in obese females.
View Article and Find Full Text PDFThe Use Of Prednisolone 2.5 mg Daily During Ramadan Fasting In Patients With Adrenal Insufficiency.
Clin Endocrinol (Oxf)
December 2024
Endocrine Unit, Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Background: A previous study had established the safety and preserved of quality of life in patients with adrenal insufficiency (AI) who received prednisolone 5 mg once daily at sahur (predawn) during Ramadan fasting. It has been postulated that a lower dose of prednisolone between 2 and 3 mg may be sufficient for glucocorticoid replacement in this group of patients. This study aimed to assess the safety and effect on quality of life in patients with AI given prednisolone 2.
View Article and Find Full Text PDFExtended-release hydrocortisone formulations - Is there a clinically meaningful benefit?
J Clin Endocrinol Metab
December 2024
Department of Clinical Medicine, University of Bergen, N-5020 BergenNorway.
Despite best practice replacement therapy with corticosteroids, patients with adrenal insufficiency report diminished quality of life and face increased mortality and morbidity. Conventional formulations of hydrocortisone have short half-lives (about 90 minutes) requiring multiple dosing during the day. Extended-release hydrocortisone (ER-HC) formulations have since 2011 been available enabling once, sometimes twice daily dosing.
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