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The visual pathway in sea spiders (Pycnogonida) displays a simple serial layout with similarities to the median eye pathway in horseshoe crabs.
BMC Biol
January 2022
Universität Greifswald, Zoologisches Institut und Museum, AG Cytologie und Evolutionsbiologie, Soldmannstraße 23, 17489, Greifswald, Germany.
Background: Phylogenomic studies over the past two decades have consolidated the major branches of the arthropod tree of life. However, especially within the Chelicerata (spiders, scorpions, and kin), interrelationships of the constituent taxa remain controversial. While sea spiders (Pycnogonida) are firmly established as sister group of all other extant representatives (Euchelicerata), euchelicerate phylogeny itself is still contested.
View Article and Find Full Text PDFInvolvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.
J Cardiovasc Transl Res
February 2021
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Despite the involvement of ɑ1adrenergic (ɑ1AR) and Histamine 2 receptors (H2R) in cardiac hypertrophy (CH), their relationship is yet to be studied. Our study investigated interrelationship between them using in vitro CH model. H9c2 cardiomyoblasts were exposed to phenylephrine (ɑ1AR agonist-50 μM) in the presence, the absence of famotidine (H2R antagonist-10 μM) and BAY 11-7082 (NF-kB inhibitor-10 μM).
View Article and Find Full Text PDFInterleukin-1 and histamine are essential for inducing nickel allergy in mice.
Clin Exp Allergy
October 2019
Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University, Sendai, Japan.
Background: We previously reported that (a) lipopolysaccharide (LPS) is a potent adjuvant for inducing Nickel (Ni) allergy in mice at both the sensitization and elicitation steps, (b) LPS induces Interleukin-1 (IL-1) and histidine decarboxylase (HDC, the histamine-forming enzyme), and IL-1 induces HDC, (c) Ni allergy is induced in mast cell-deficient, but not IL-1-deficient (IL-1-KO) or HDC-KO mice.
Objective: To examine the roles of IL-1 and HDC (or histamine) and their interrelationship during the establishment of Ni allergy.
Methods: Ni (NiCl ) 1 mmol/L containing IL-1β and/or histamine was injected intraperitoneally (sensitization step).
The low affinity neurotensin receptor antagonist levocabastine impairs brain nitric oxide synthesis and mitochondrial function by independent mechanisms.
J Neurochem
December 2017
Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Neurotensin is known to inhibit neuronal Na , K -ATPase, an effect that is rescued by nitric oxide (NO) synthase inhibition. However, whether the neurotensinergic and the nitrergic systems are independent pathways, or are mechanistically linked, remains unknown. Here, we addressed this issue and found that the administration of low affinity neurotensin receptor (NTS2) antagonist, levocabastine (50 μg/kg, i.
View Article and Find Full Text PDFRole of histamine in the regulation of intestinal immunity in fish.
Dev Comp Immunol
November 2016
Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, IMIB-Arrixaca, Campus Universitario de Espinardo, Murcia 30100, Spain. Electronic address:
In mammals, during the acute inflammatory response, the complex interrelationship and cross-talk among histamine and the immune system has been fairly well characterized. There is a substantial body of information on its structure, metabolism, receptors, signal transduction, physiologic and pathologic effects. However, for early vertebrates, there is little such knowledge.
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