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Local cortical structure pattern and genetic links in schizophrenia: An MRI and CRISPR/Cas9 study.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Institute of Brain Science, National Yang-Ming Chiao Tung University, Taipei 11221, Taiwan; Brain Research Center, National Yang-Ming Chiao Tung University, Taipei 11221, Taiwan; Digital Medicine and Smart Healthcare Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:
While the etiology of schizophrenia (SZ) remains elusive, its diverse phenotypes suggest the involvement of distinct functional cortical areas, and the heritability of SZ implies the underlying genetic factors. This study aimed to integrate imaging and molecular analyses to elucidate the genetic underpinnings of SZ. We investigated the local cortical structural pattern changes in Brodmann areas (BAs) by calculating the cortical structural pattern index (SPI) using magnetic resonance imaging analysis from 194 individuals with SZ and 330 controls.
View Article and Find Full Text PDFEfficient removal of pharmaceuticals from wastewater: Comparative study of three advanced oxidation processes.
J Environ Manage
January 2025
Department of Separation Science, School of Engineering Science, Lappeenranta-Lahti University of Technology (LUT), Yliopistonkatu 34, 53850, Lappeenranta, Finland.
As the global consumption of pharmaceuticals increases, so does their release into water bodies. The effects, although not fully understood, can be detrimental to aquatic ecosystems and human health. The new Urban Wastewater Treatment Directive (UWWTD) in European Union requires implementation of quaternary wastewater treatment processes to limit the loads of pharmaceuticals reaching water bodies.
View Article and Find Full Text PDFA temperature-inducible protein module for control of mammalian cell fate.
Nat Methods
January 2025
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Inducible protein switches are currently limited for use in tissues and organisms because common inducers cannot be controlled with precision in space and time in optically dense settings. Here, we introduce a protein that can be reversibly toggled with a small change in temperature, a stimulus that is both penetrant and dynamic. This protein, called Melt (Membrane localization using temperature) oligomerizes and translocates to the plasma membrane when temperature is lowered.
View Article and Find Full Text PDFAt early stages of heart development, the first and second heart fields are a continuum of lateral head mesoderm-derived, cardiogenic cells.
Dev Biol
January 2025
Institute of Life Sciences and Health (ILSH), School of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK. Electronic address:
Pioneering work in the chicken established that the initial development of the heart consists of two stages: the quick assembly of a beating heart, followed by the recruitment of cells from adjacent tissues to deliver the mature in-and outflow tract. Cells to build the primitive heart were dubbed the first heart field (FHF) cells, cells to be recruited later the second heart field (SHF) cells. The current view is that these cells represent distinct, maybe even pre-determined lineages.
View Article and Find Full Text PDFPARP12-mediated ADP-ribosylation contributes to breast cancer cell fate by regulating AKT activation and DNA-damage response.
Cell Mol Life Sci
January 2025
Institute of Endotypes in Oncology, Metabolism, and Immunology, National Research Council, Via Pietro Castellino 111, Naples, Italy.
Breast cancer represents the primary cause of death of women under 65 in developed countries, due to the acquisition of multiple drug resistance mechanisms. The PI3K/AKT pathway is one of the major regulating mechanisms altered during the development of endocrine resistance and inhibition of steps in this signalling pathway are adopted as a key strategy to overcome this issue. ADP-ribosylation is a post-translational modification catalysed by PARP enzymes that regulates essential cellular processes, often altered in diseases.
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