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Successful Treatment of Primary Acanthamoeba Cutis in a Patient With Chronic Lymphocytic Leukemia on Acalabrutinib.
Am J Dermatopathol
December 2024
Department of Dermatology, Vagelos College of Physician and Surgeons of Columbia University and New York Presbyterian Hospital, New York, NY; and.
Primary cutaneous amoebiasis is rare, and typically affects immunocompromised patients and presents with unique clinical and histopathologic changes. Untreated, the infection could progress to involve the central nervous system, which is almost universally fatal. We present a case of primary cutaneous acanthamoebiasis in a patient with chronic lymphocytic leukemia on acalabrutinib.
View Article and Find Full Text PDFDiplopstomiasis and acanthamoebiasis syndromes in the different organs of Oreochromis aureus collected from Lake Manzala.
Open Vet J
November 2024
Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt.
Background: is a member of the tilapia family that is considered one of the main food sources in different countries all over the world.
Aim: Thus, studying the different pathogens infecting tilapia species is still one of the interesting search points.
Methods: One hundred and eighty specimens of were collected from Lake Manzala and transported directly in iceboxes to the laboratory of the faculty of Science at Port Said University.
Transcriptomic profiling of "brain-eating amoeba" infection in mice: the host and the protozoa perspectives.
Front Cell Infect Microbiol
December 2024
Institut Pasteur de la Guadeloupe, Les Abymes, Guadeloupe, France.
The free-living amoeba (NF) causes a rare but lethal parasitic meningoencephalitis (PAM) in humans. Currently, this disease lacks effective treatments and the specific molecular mechanisms that govern NF pathogenesis and host brain response remain unknown. To address some of these issues, we sought to explore naturally existing virulence diversity within environmental NF isolates.
View Article and Find Full Text PDF-induced NETs are highly cytotoxic on hepatic and colonic cells due to serine proteases and myeloperoxidase activities.
Front Immunol
December 2024
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, Mexico.
During intestinal and liver invasion by the protozoan parasite , extensive tissue destruction linked to large neutrophil infiltrates is observed. It has been proposed that microbicidal components of neutrophils are responsible for the damage, however, the mechanism by which they are released and act in the extracellular space remains unknown. In previous studies, we have shown that trophozoites induce NET formation, leading to the release of neutrophil granule content into extruded DNA.
View Article and Find Full Text PDF[Balamuthia mandrillaris amebic encephalitis: report of a case].
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, Affiliated Hospital of Hebei University, Baoding071000, China.
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