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Aminophylline at clinically relevant concentrations affects inward rectifier potassium current in healthy porcine and failing human cardiomyocytes in a similar manner.
Biomed Pharmacother
December 2024
ICRC, St. Anne's University Hospital, Pekařská 53, Brno 602 00, Czech Republic; 1st Department of Internal Medicine, Cardio-Angiology, Faculty of Medicine, Masaryk University, Pekařská 53, Brno 602 00, Czech Republic.
Article Synopsis
- - Aminophylline, a medication often used for severe asthma, can cause arrhythmias, but the exact reasons are not clear
- - In research, aminophylline significantly inhibited the inward rectifier potassium current in both healthy pig heart cells and failing human heart cells at different concentrations
- - The study found that aminophylline prolonged action potential duration in porcine heart cells, indicating its potential role in causing arrhythmias, suggesting further exploration of its effects on other ionic currents is necessary
Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model.
Sci Rep
November 2024
Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
The combination of aminophylline and salbutamol is frequently used in clinical practice in the treatment of obstructive lung diseases. While the side effects (including arrhythmias) of the individual bronchodilator drugs were well described previously, the side effects of combined treatment are almost unknown. We aimed to study the arrhythmogenic potential of combined aminophylline and salbutamol treatment in vitro.
View Article and Find Full Text PDFAminophylline Improves Ventilator-Induced Diaphragmatic Dysfunction by Targeting IGF-1-FOXO1-MURF1 Pathway.
Discov Med
April 2024
Department of ICU/Emergency, Wuhan Third Hospital & Tongren Hospital of Wuhan University, 430070 Wuhan, Hubei, China.
Article Synopsis
- - The study investigates the effects of aminophylline (AP) on ventilator-induced diaphragmatic dysfunction (VIDD), which increases mortality and morbidity in patients needing mechanical ventilation. It focuses on the involvement of the IGF-1-FOXO1-MURF1 pathway in this dysfunction.
- - Rat models with VIDD were treated with mechanical ventilation, and various techniques (like lentiviral interference and western blot) were used to analyze protein and mRNA levels, diaphragm contractility, oxidative stress, and mitochondrial stability.
- - The findings aim to shed light on how AP might ameliorate VIDD and its associated mechanisms, including mitochondrial dynamics and apoptosis, which could lead to improved treatment strategies for patients requiring mechanical
Carvacrol-Loaded Nanoemulsion Promotes Tocolytic and Anti-Dysmenorrhea Effects in Rodents.
Pharmacology
April 2024
Programa de Pós-Graduação em Biociências, Universidade Federal do Vale do São Francisco (UNIVASF), Petrolina,, Brazil.
Introduction: Carvacrol is a phenolic constituent of essential oils that has antinociceptive, anti-inflammatory, and antioxidant activities.
Method: This study aimed to evaluate the in vitro spasmolytic and in vivo anti-dysmenorrhea potential of a nanoemulsion-containing carvacrol (nanoCARV).
Results: In isolated rat uterus, nanoCARV reduced spontaneous contractions (pEC50 = 3.
New phosphodiesterase-4 inhibitors present airways relaxant activity in a guinea pig acute asthma model.
Naunyn Schmiedebergs Arch Pharmacol
June 2024
Laboratório de Farmacologia Funcional Professor George Thomas, Instituto de Pesquisa em Fármacos e Medicamentos, Universidade Federal da Paraíba, João Pessoa, Brazil.
Asthma is a disease characterized by chronic inflammation and hyper responsiveness of airways. We aimed to assess the relaxant potential of phosphodiesterase-4 (PDE4) inhibitors N-sulfonilhidrazonic derivatives on non-asthmatic and asthmatic guinea pig trachea. Firstly, guinea pigs were sensitized and challenged with ovalbumin, and then morphological, and contractile changes were evaluated resulting from asthma, followed by evaluation of relaxant effect of derivatives on guinea pig trachea and the cAMP levels measurement by ELISA.
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