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Schistosoma japonicum cathepsin B2 (SjCB2) facilitates parasite invasion through the skin.
PLoS Negl Trop Dis
October 2020
Department of infectious diseases, Huashan Hospital, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, China.
Cercariae invasion of the human skin is the first step in schistosome infection. Proteases play key roles in this process. However, little is known about the related hydrolytic enzymes in Schistosoma japonicum.
View Article and Find Full Text PDFEfficiency of ginger (Zingbar officinale) against Schistosoma mansoni infection during host-parasite association.
Parasitol Int
August 2013
Therapeutical Chemistry Department, National Research Center, Giza, Egypt.
The possible protective effect of ethanolic extract of ginger against infection with Schistosome mansonii was evaluated in mice. The extract was given daily for 45 days beginning at either 2nd day or 45 days post infection. Oral supplementation of ginger extract to infected animals was effective in reducing worm burden and the egg load in the liver and intestine which coincided with the reduction in granuloma diameters.
View Article and Find Full Text PDFSynthesis and bioactivities of two multiple antigen peptides as potential vaccine against schistosoma.
Bioorg Med Chem Lett
May 2005
Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.
Based on the two antigenic peptides, 26-43 (P26) and 116-131 (P116), derived from 28 kDa glutathione S-transferase of Schistosoma mansoni (Sm28GST), two multiple antigenic peptides (MAPs), (P26)4-MAP and (P116)4-MAP with the same oligomeric lysine core, were synthesized by stepwise solid-phase peptide synthesis method. The antigenicities and protective effects of these two MAPs were examined on experimental animals. As shown in the dot-ELISA result, the synthetic MAPs could be recognized and bound by immunoglobins in both patient's and infected-rabbit's sera.
View Article and Find Full Text PDFCorrelation between infection intensity, serum immunoglobulin profile, cellular immunity and the efficacy of treatment with praziquantel in murine schistosomiasis mansoni.
Arzneimittelforschung
February 2000
Department of Parasitology, Theodor Bilharz Research Institute, Imbaba, Guiza, Egypt.
This study was conducted to evaluate the efficacy of praziquantel (CAS 55268-74-1, EMBAY 8440, Biltricide) in different grades of Schistosoma mansoni infection. Moreover, the relationship between the post treatment worm burden, hepatic granuloma volume, and serum immunoglobin profile was also investigated. Four groups of Swiss albino mice infected with Schistosoma mansoni cercariae were used: Highly infected untreated control mice (infected with 120 Schistosoma mansoni cercariae) and their corresponding praziquantel treated group.
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