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Phenotypes, Genotypes, Treatment, and Outcomes of 14 Children with Sitosterolemia at Vietnam National Children's Hospital.
J Clin Med
January 2025
Hanoi Medical University, 1st Ton That Tung Street, Hanoi 11521, Vietnam.
: Sitosterolemia is a rare autosomal recessive disorder characterized by diverse clinical manifestations ranging from asymptomatic cases to the development of xanthomas, hypercholesterolemia, premature atherosclerosis, or even sudden death during childhood. It results from homozygous or compound heterozygous pathogenic variants in the or genes. Prompt detection and intervention are essential to managing this condition and preventing severe outcomes.
View Article and Find Full Text PDFBile acid sequestrant inhibits gluconeogenesis via inducing hepatic cysteine dioxygenase type 1 to reduce cysteine availability.
Am J Physiol Gastrointest Liver Physiol
January 2025
Harold Hamm Diabetes Center, Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104.
Bile acid sequestrants such as cholestyramine (ChTM) are gut-restricted bile acid binding resins that block intestine bile acid absorption and attenuate hepatic bile acid signaling. Bile acid sequestrants induce hepatic bile acid synthesis to promote cholesterol catabolism and are cholesterol lowering drugs. Bile acid sequestrants also reduce blood glucose in clinical trials and are approved drugs for treating hyperglycemia in type-2 diabetes.
View Article and Find Full Text PDFManagement of perioperative thyrotoxicosis - what to do when standard therapy is contraindicated or fails?
Front Endocrinol (Lausanne)
December 2024
Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.
Background: Current guidelines recommend that hyperthyroid patients should be rendered euthyroid prior to surgical procedures. These guidelines rely heavily on the use of ATDs as the primary medication, and do not give recommendations for patients who have contraindications to ATDs, or for whom standalone ATD treatment is inadequate.
Objectives: To evaluate the efficacy and safety of adjunctive pharmacological therapy and/or therapeutic plasma exchange (TPE) in the perioperative management of patients with thyrotoxicosis who were intolerant to ATD or for whom standalone ATD therapy was inadequate to achieve euthyroidism prior to surgery.
Influence of gut bile acid composition on the glucose-lowering effect and safety of metformin.
Br J Clin Pharmacol
December 2024
Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Republic of Korea.
Article Synopsis
- The study investigates how cholestyramine, a bile acid sequestrant, influences the effectiveness of metformin in lowering blood glucose levels by altering intestinal bile acid composition.
- It involved healthy male adults in a two-period crossover design, where participants received metformin alone in the first period and with cholestyramine in the second, measuring various glucose response parameters.
- Results showed that cholestyramine further decreased the glucose-lowering effects of metformin and improved the associated side effect of diarrhea in some participants.
Sepiolite-Chitosan-Acetic Acid Biocomposite Attenuates the Development of Obesity and Nonalcoholic Fatty Liver Disease in Mice Fed a High-Fat Diet.
Nutrients
November 2024
Laboratory of Integrative Physiology, The Department of Nutrition and Natural Products, MIGAL-Galilee Research Institute, P.O. Box 831, Kiryat Shmona 11016, Israel.
Background; obesity and nonalcoholic fatty liver disease (NAFLD) reduce life expectancy; nonoperative interventions show poor results. Individually, chitosan (1% /), acetic acid (AA 0.3-6.
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