Voltage clamping giving step commands reveals a steady-state negative resistance characteristic in the current-voltage curves of Aplysia bursting neurons. This is observed below spike threshold in the unstable range through which the membrane potential slowly oscillates. The negative resistance characteristic underlies this instability and shapes the rapid depolarization-hyper-polarization phase of the cycle. When bursting cells are converted to silent cells (by cooling) the negative resistance is abolished; conversely, when normally silent cells are made to burst (by warming) a negative resistance develops. The presence of negative resistance thus enables the bursting cell to oscillate, whereas its absence precluldes such oscillations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/science.186.4167.932 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predictive Factors of Alcohol Initiation among Brazilian Adolescents: Assessing the Role of Attitudes, Decision-Making, Communication, and Resistance Skills.
Braz J Psychiatry
January 2025
Department of Preventive Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Objective: This study aims to evaluate if attitudes toward drug use, decision-making, communication, and alcohol resistance skills act as predictors of alcohol use and binge drinking initiation among Brazilian students, considering the sex differences.
Methods: We used a longitudinal sample of 1,103 seventh-grade students from 15 Brazilian public schools. We explored if attitudes toward drug use, decision-making, communication, and alcohol resistance skills at baseline predicted alcohol outcomes nine months later.
Dementia Diagnosis Unawareness and Caregiver Burden in a Multi-ethnic Cohort.
J Gen Intern Med
January 2025
Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.
Background: Previous reports suggest patient and caregiver lack of awareness of dementia. Little is known about how this varies by ethnicity and how informal (family) caregiver burden is associated with knowing a dementia diagnosis.
Objective: To investigate whether participants with probable dementia were aware of a diagnosis provided by a physician and how this differed among Mexican American and non-Hispanic White participants; whether having a primary care physician was associated with dementia diagnosis unawareness; and the association of dementia diagnosis unawareness with caregiver burden.
Correction to "Rapeseed PP2C37 Interacts with PYR/PYL Abscisic Acid Receptors and Negatively Regulates Drought Tolerance".
J Agric Food Chem
January 2025
State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Life Sciences, Northwest A & F University, Yangling, Shaanxi 712100, People's Republic of China.
Background: Due to its increasing prevalence and suboptimal treatment, non-tuberculous mycobacterial (NTM) infection is an emerging problem in patients with cystic fibrosis (CF). Detailed description of regional NTM prevalence and distribution, and identification of predictors of NTM acquisition in CF are essential to optimise treatment and surveillance guidelines.
Methods: A retrospective, multi-center analysis was conducted between the years 2020 and 2022 on data from 232 adult patients registered in the Hungarian CF Registry in 2022.
Objectives: Intensive care unit (ICU) clinicians stop antibiotics more often, with a negative infection: point-of-care test (PCR-POCT). Simulated cases of diagnostic uncertainty regarding infection resolution led clinicians to choose options such as procalcitonin (PCT) and/or PCR-POCTs +/- de-escalation to aid stop decisions. We hypothesised that a direct infection indicator, PCR-POCT, would influence stop judgements more than indirect PCT.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!