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Phosphodiesterase inhibition restoreshypoxia-induced cerebrovascular dysfunction subsequent to improved systemic redox homeostasis: A randomized, double-blind, placebo-controlled crossover study.
J Cereb Blood Flow Metab
January 2025
Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.
To what extent sildenafil, a selective inhibitor of the type-5 phosphodiesterase modulates systemic redox status and cerebrovascular function during acute exposure to hypoxia remains unknown. To address this, 12 healthy males (aged 24 ± 3 y) participated in a randomized, placebo-controlled crossover study involving exposure to both normoxia and acute (60 min) hypoxia (Fi = 0.14), followed by oral administration of 50 mg sildenafil and placebo (double-blinded).
View Article and Find Full Text PDFApplication of Cardiac Rehabilitation Aerobic Exercise in Patients with Stable Angina in Coronary Heart Disease.
Br J Hosp Med (Lond)
January 2025
Department of Sports Arts, Hebei Sport University, Shijiazhuang, Hebei, China.
A novel exercise protocol for cardiac rehabilitation aerobic (CRA) has been developed by Hebei Sport University, demonstrating efficacy in patients with coronary heart disease (CHD). The objective of this study was to evaluate the impact of CRA on precise cardiac rehabilitation (CR) for CHD patients presenting with stable angina pectoris. The study cohort comprised patients with stable angina who were categorized into three groups: the CRA group (n = 35), the power bicycles (PB) group (n = 34), and the control group (n = 43).
View Article and Find Full Text PDFCirculating neuropeptide Y dynamics and performance during exercise in heart failure patients with contemporary medical and device therapy.
Exp Physiol
January 2025
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
High cardiac sympathetic drive and release of the sympathetic cotransmitter neuropeptide Y (NPY) are significant features of congestive heart failure (CHF), in which resting venous NPY levels are known to be associated with mortality. However, whether circulating NPY levels increase during exercise in CHF when they are already elevated is controversial. We sought to establish the dynamics of circulating NPY levels in CHF patients treated with contemporary medical therapy and devices in relationship to indices of performance linked to long-term prognosis.
View Article and Find Full Text PDFAnalysis of the Effect of Skin Pigmentation and Oxygen Saturation on Monte Carlo-Simulated Reflectance Photoplethysmography Signals.
Sensors (Basel)
January 2025
Research Centre for Biomedical Engineering, City St George's, University of London, London EC1V 0HB, UK.
The effect of skin pigmentation on photoplethysmography and, specifically, pulse oximetry has recently received a significant amount of attention amongst researchers, especially since the COVID-19 pandemic. With most computational studies observing overestimation of arterial oxygen saturation (SpO) in individuals with darker skin, this study seeks to further investigate the root causes of these discrepancies. This study analysed intensity changes from Monte Carlo-simulated reflectance PPG signals across light, moderate, and dark skin types at oxygen saturations of 70% and 100% in MATLAB R2024a.
View Article and Find Full Text PDFA New Approach to Non-Invasive Microcirculation Monitoring: Quantifying Capillary Refill Time Using Oximetric Pulse Waves.
Sensors (Basel)
January 2025
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, 168 Litang Road, Changping District, Beijing 102218, China.
(1) Background: To develop a novel capillary refill time measurement system and evaluate its reliability and reproducibility. (2) Methods: Firstly, the utilization of electromagnetic pressure technology facilitates the automatic compression and instantaneous release of the finger. Secondly, the employment of pressure sensing technology and photoelectric volumetric pulse wave analysis technology enables the dynamic monitoring of blood flow in distal tissues.
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