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Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle.
J Clin Endocrinol Metab
January 2025
Division of Pediatric Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Introduction: Friedreich's ataxia (FRDA) is a multisystem disorder caused by frataxin deficiency. FRDA-related diabetes mellitus (DM) is common. Frataxin supports skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) capacity, a mediator of insulin sensitivity.
View Article and Find Full Text PDFSleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea.
Healthcare (Basel)
March 2024
Department of Pneumonology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Study Objectives: The aim of this cross-sectional study is to explore the association between serum 25-hydroxyvitamin D [25(OH)D] levels, a marker of Vitamin D status, and excessive daytime sleepiness (EDS), expressed as increased scores of the Epworth Sleepiness Scale (ESS), in a group of prospectively enrolled patients with obstructive sleep apnea (OSA).
Methods: Newly diagnosed patients with OSA, divided into two groups, those with EDS (ESS > 10) and those without EDS (ESS < 10). All patients underwent night polysomnography.
Correlation between diminished vagal tone and somatic dysfunction severity in very and extremely low birth weight preterm infants assessed with frequency spectrum heart rate variability and salivary cortisol.
Medicine (Baltimore)
September 2022
Neonatal Intensive Care Unit, Woman and Child Department, Del Ponte Hospital, Varese, Italy.
Osteopathic manipulative treatment (OMT) is evolving in the neonatal intensive care unit (NICU) setting. Studies showed its efficacy in length of stay and hospitalization costs reduction. Moreover, it was suggested that OMT has a modulatory effect on the preterm infants' autonomic nervous system (ANS), influencing saturation and heart rate.
View Article and Find Full Text PDFThe History of Testosterone and the Evolution of its Therapeutic Potential.
Sex Med Rev
April 2020
Boston University School of Medicine, Boston, MA, USA.
Introduction: Testosterone therapy has been controversial since its synthesis in the 1930s to the present day. Testosterone's history provides depth and context for current controversies.
Aim: To review the history of testosterone therapy from its initial synthesis in the 1930s to the modern day.
Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways.
J Behav Med
December 2017
School of Medicine/Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.
This study examined the association between depressive symptoms, as well as depressive symptom dimensions, and three candidate biological pathways linking them to Obstructive sleep apnea (OSA): (1) inflammation; (2) circulating leptin; and (3) intermittent hypoxemia. Participants included 181 obese adults with moderate-to-severe OSA enrolled in the Cardiovascular Consequences of Sleep Apnea (COSA) trial. Depressive symptoms were measured using the Beck Depression Inventory-II (BDI-II).
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