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Expression, Sarkosyl Solubilization, DNase Activity, Purification, and SPR Binding Affinity of Recombinant Diphtheria Toxoid (rCRM197EK) Expressed in Escherichia coli BL21(DE3).
Mol Biotechnol
August 2024
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang, 45363, West Java, Indonesia.
CRM197EK is a derivative of diphtheria toxoid cross-reactive material-197 (CRM197) with two-point mutations (K51E and E148K) to improve its properties for a vaccine conjugate and drug delivery. A previous study has shown that intracellularly expressing CRM197EK in Escherichia coli (E. coli) host formed inclusion bodies that need a complicated purification and refolding step.
View Article and Find Full Text PDFDiphtheria-Associated Myocarditis: Clinical Profiles and Mortality Trends in a Tertiary Care Hospital in Pakistan.
Cureus
March 2024
Pediatric Cardiology, Lady Reading Hospital, Peshawar, PAK.
Article Synopsis
- - The study investigates diphtheria-induced myocarditis in children, highlighting its public health significance in Pakistan despite ongoing immunization, particularly through recent outbreaks since 2022.
- - Conducted at Lady Reading Hospital, the research analyzed data from 73 pediatric patients, evaluating demographic information along with cardiac performance metrics such as ECG and echocardiography results.
- - Results indicated a variety of cardiac issues among patients, with most receiving anti-diphtheria serum treatment, and the study suggests further exploration of gender-based differences in clinical outcomes for enhancing care and prevention strategies.
Antibody feedback regulation of memory B cell development in SARS-CoV-2 mRNA vaccination.
medRxiv
August 2022
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Feedback inhibition of humoral immunity by antibodies was initially documented in guinea pigs by Theobald Smith in 1909, who showed that passive administration of excess anti-Diphtheria toxin inhibited immune responses. Subsequent work documented that antibodies can enhance or inhibit immune responses depending on antibody isotype, affinity, the physical nature of the antigen, and engagement of immunoglobulin (Fc) and complement (C') receptors. However, little is known about how pre-existing antibodies might influence the subsequent development of memory B cells.
View Article and Find Full Text PDFThe recombinant protein combined vaccine based on the fragment C of tetanus toxin and the cross-reacting material 197.
Appl Microbiol Biotechnol
February 2021
Jiangsu Theravac Bio-pharmaceutical CO., Ltd, No.699-18 Xuanwu Street, Nanjing, 210042, China.
Diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccines were widely used since 1940s. The exceptional success of childhood vaccination is undisputed. However, the anti-diphtheria and tetanus antibody will decrease with the increase of age in human body.
View Article and Find Full Text PDFSeroprevalence of Maternal and Cord Antibodies Specific for Diphtheria, Tetanus, Pertussis, Measles, Mumps and Rubella in Shunyi, Beijing.
Sci Rep
August 2018
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Maternal antibodies contribute to the protection of young infants from infectious diseases during the early life. However, vaccinations for women of child-bearing age are not routine in China. Therefore, we investigated the level of protective immunity against vaccine preventable diseases in pregnant women and newborns in China.
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