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Introduction And Importance: Solitary extramedullary plasmacytoma (SEP) is a rare plasma cell neoplasm, constituting around 3 % of plasma cell malignancies. SEP typically presents as a single tumor, either in bone or soft tissue, without systemic disease, and is often misdiagnosed due to its nonspecific symptoms. Diagnosis requires biopsy and extensive imaging studies to exclude multiple myeloma and other malignancies.

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Multiple myeloma (MM) remains incurable despite novel therapeutics. A major contributor to the development of relapsed/refractory and resistant MM is extraosseous extramedullary disease (EMD), whose molecular biology is still not fully understood. We analyzed 528 MM patients who presented to our institution between 2014 and 2021 and who had undergone molecular testing.

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We report the case of a 60-year-old man diagnosed with unilateral, solitary, extramedullary plasmacytoma located in the right lacrimal sac fossa, with no systemic involvement. This rare plasma cell dyscrasia is usually found in the respiratory tract. Clinical and radiological features of the mass and histopathological results are described.

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Primary pulmonary plasmacytoma: A case report.

Medicine (Baltimore)

December 2024

Department of Respiratory and Critical Care Medicine, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

Article Synopsis
  • Extramedullary plasmacytoma is a rare malignant tumor found in tissues outside of bone marrow, with primary pulmonary plasmacytoma (PPP) being particularly uncommon and diagnosed through biopsy.
  • A 65-year-old woman experienced chronic cough and was hospitalized with acute chest pain, where imaging revealed extensive lung inflammation.
  • The diagnosis was confirmed via bronchoscopy, leading to hormone anti-inflammatory treatment; however, the patient was lost to follow-up, emphasizing the need for awareness and biopsy in similar cases to ensure proper diagnosis and management of PPP.
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