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Private and well drinking water are reservoirs for antimicrobial resistant bacteria.
NPJ Antimicrob Resist
March 2024
Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.
Water quality testing does not recognise antimicrobial resistance (AMR) and is often limited to indicators of faecal contamination Escherichia coli and Enterococcus species. In Europe, data on AMR in drinking water is scarce. In Ireland, as in many countries, household drinking water is supplied via mains or via private wells or water schemes.
View Article and Find Full Text PDFAnalysis of retinal sublayers in patients with systemic COVID-19 illness with varying degrees of severity.
Sci Rep
January 2025
Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
COVID-19 infection has been linked to ocular involvement, particularly retinal microvascular changes. Additionally, prolonged hypoxemia may affect retinal sublayers located within the retinal watershed zone. The aim of this study was to evaluate retinal and optic nerve OCT parameters in patients with COVID-19 illness of varying severity and compare them with controls.
View Article and Find Full Text PDFRapid resistance profiling of SARS-CoV-2 protease inhibitors.
NPJ Antimicrob Resist
August 2023
Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, 78229, TX, USA.
Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a robust cell-based assay is used to determine the relative potencies of nirmatrelvir, ensitrelvir, and FB2001 against a panel of SARS-CoV-2 main protease (M) variants. The results reveal that these three drugs have at least partly distinct resistance mutation profiles and raise the possibility that the latter compounds may be effective in some instances of Paxlovid resistance and vice versa.
View Article and Find Full Text PDFKnown mechanisms cannot account for a third of reduced susceptibility in non-aureus staphylococci.
NPJ Antimicrob Resist
November 2023
Medical Microbiology Research Laboratory, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ, UK.
Non-aureus staphylococci (NAS) are implicated in many healthcare-acquired infections and an understanding of the genetics of antimicrobial resistance is important in relation to both clinical intervention and the role of NAS as a reservoir of resistance genes. Gap statement: The burden of antimicrobial resistance in NAS, particularly to clinically relevant antimicrobials, is under-recognised. We sourced 394 NAS isolates from clinical samples, healthy human volunteers, animals and type cultures and subjected them to minimum inhibitory concentration (MIC) testing by agar dilution using eight antimicrobials.
View Article and Find Full Text PDFFrom node to network: weaving a global perspective on efficacy and costs of non-pharmaceutical interventions.
Sci Rep
January 2025
Information and Operations Management Department, University of Michigan - Dearborn, Dearborn, MI, USA.
Non-pharmaceutical intervention (NPI) policies, ranging from mild measures to total isolation, were implemented worldwide during the COVID-19 pandemic. We adopt a systematic approach to guide policymakers in deploying NPI policies to mitigate the pandemic's effects while balancing their social and economic impacts. Our results show that each NPI has an optimal duration, beyond which its effectiveness plateaus.
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