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Non-invasive fundoscopy as a tool to estimate intracranial pressure: a large animal model.
Acta Neurochir (Wien)
January 2025
Department of Neurosurgery, Odense University Hospital, Odense, Denmark.
Purpose: Intracranial pressure (ICP) monitoring is in most studies considered essential in avoiding secondary brain injury in patients with intracranial pathologies. Invasive monitoring of ICP is accurate but is unavailable in many clinical and prehospital settings. Non-invasive modalities have historically been difficult to implement clinically.
View Article and Find Full Text PDFEnhancing glaucoma diagnosis: Generative adversarial networks in synthesized imagery and classification with pretrained MobileNetV2.
MethodsX
June 2025
Department of Computer Science and Engineering, Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and Technology, Tamil Nadu 600062, India.
The disease affects the optic nerve and represents the principle reasons of irreversible vision loss, mostly asymptomatic and uncontrolled. Consequently, early and accurate diagnosis is critical to prevent or reduce its effect, however, conventional diagnostic techniques often fail to provide concrete results. In this regard, we present a new approach built on Generative Adversarial Networks (GAN) and MobileNetV2 pretrained architecture for diagnosing glaucoma.
View Article and Find Full Text PDFMachine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology.
Nat Commun
January 2025
NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & University College London Institute of Ophthalmology, London, UK.
Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as a surrogate marker for biological variability. We derived a continuous, measured metric, the retinal pigment score (RPS), that quantifies the degree of pigmentation from a colour fundus photograph of the eye. RPS was validated using two large epidemiological studies with demographic and genetic data (UK Biobank and EPIC-Norfolk Study) and reproduced in a Tanzanian, an Australian, and a Chinese dataset.
View Article and Find Full Text PDFAngiographic features of pediatric stage 4 familial exudative vitreoretinopathy with radial retinal folds.
Graefes Arch Clin Exp Ophthalmol
December 2024
Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang Road, No. 1665, Shanghai, 200092, China.
Purpose: To describe vascular anomalies and nonperfusion areas (NPAs) of stage 4 familial exudative vitreoretinopathy (FEVR) with radial retinal folds (RFs) and analyze their potential clinical significance.
Methods: Retinal detachment (RD) could exceed the RFs due to exudative, rhegmatogenous, or tractional factors, which we could call secondary RD. Fluorescein fundus angiography (FFA) and risk factors for progression to secondary RD of pediatric stage 4 FEVR patients with radial RFs were respectively explored.
Exudative perifoveal vascular anomalous complex (ePVAC) resembling lesion in a patient with adult-onset foveomacular vitelliform dystrophy.
Am J Ophthalmol Case Rep
December 2024
Eye Clinic, Department of Medical Surgical Sciences and Health, University of Trieste, 34129, Trieste, Italy.
Purpose: to report a case of exudative perifoveal vascular anomalous complex (ePVAC) in a patient with adult-onset foveomacular vitelliform dystrophy.
Observations: A 71-year-old male presented with moderate vision loss in his left eye. His past medical and ocular history were unremarkable.
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