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Immunogenicity analysis based on VP1 and VP2 proteins of bovine enterovirus.
Virology
December 2024
Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, China; Guangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, Nanning, China. Electronic address:
Article Synopsis
- - Bovine enterovirus (BEV) infections can lead to various symptoms in cattle, impacting their respiratory, gastrointestinal, and reproductive health, and causing significant economic losses in the bovine industry globally.
- - The study utilized a method called reverse transcription-polymerase chain reaction to create a chimeric protein from BEV's VP1 and VP2 genes, which was then used to immunize mice and test for immune response.
- - Results indicated that this immunization reduced virus shedding and tissue damage, improving overall health in the infected animals, which supports the potential for developing a vaccine against BEV.
Epidemiological survey of calf diarrhea related viruses in several areas of Guangdong Province.
Front Microbiol
September 2024
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Article Synopsis
- Various bovine viruses like BToV, BEV, BNoV, BCoV, BRV, and BVDV are major causes of diarrhea in calves and pose challenges in terms of prevention and control.
- In a study of 295 calf diarrhea samples from Guangdong Province, the overall viral positivity rate was found to be 21.36%, with the highest rates in Foshan and Guangzhou cities.
- The study marks the first detection of BToV and BNoV in this region and reveals significant genetic similarities among the viral strains, indicating connections to epidemic strains found in other provinces of China.
The early communication stages between serine proteases and enterovirus capsids in the race for viral disintegration.
Commun Biol
August 2024
Laboratory of Environmental Virology, Environmental Engineering Institute (IIE), School of Architecture, Civil and Environmental Engineering (ENAC), Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015-CH, Lausanne, Switzerland.
Serine proteases are important environmental contributors of enterovirus biocontrol. However, the structural features of molecular interaction accounting for the susceptibility of enteroviruses to proteases remains unexplained. Here, we describe the molecular mechanisms involved in the recruitment of serine proteases to viral capsids.
View Article and Find Full Text PDFConstruction of an IFNAR1 knockout MDBK cell line using CRISPR/Cas9 and its effect on bovine virus replication.
Front Immunol
August 2024
State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Article Synopsis
- The study focuses on developing a type I interferon receptor knockout (IFNAR1 KO) cell line in bovine kidney cells to understand its impact on viral replication.
- Findings showed that IFNAR1 KO cells significantly increased the replication of bovine viral diarrhea virus (BVDV) and other bovine viruses by altering gene expression related to immune response and cell signaling.
- The research highlights the potential of the IFNAR1 KO cell line as a valuable tool for studying bovine virus interactions and the host's innate immune response.
β-D-glucuronidase activity triggered monitoring of fecal contamination using microbial and chemical source tracking markers at drinking water intakes.
Water Res
May 2024
Canada Research Chair in Source Water Protection, Department of Civil, Geological, and Mining Engineering, Polytechnique Montréal, QC, H3C 3A7, Canada.
Intense rainfall and snowmelt events may affect the safety of drinking water, as large quantities of fecal material can be discharged from storm or sewage overflows or washed from the catchment into drinking water sources. This study used β-d-glucuronidase activity (GLUC) with microbial source tracking (MST) markers: human, bovine, porcine mitochondrial DNA markers (mtDNA) and human-associated Bacteroidales HF183 and chemical source tracking (CST) markers including caffeine, carbamazepine, theophylline and acetaminophen, pathogens (Giardia, Cryptosporidium, adenovirus, rotavirus and enterovirus), water quality indicators (Escherichia coli, turbidity) and hydrometeorological data (flowrate, precipitation) to assess the vulnerability of 3 drinking water intakes (DWIs) and identify sources of fecal contamination. Water samples were collected under baseline, snow and rain events conditions in urban and agricultural catchments (Québec, Canada).
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