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Design and Validation of a High-Fidelity Left Atrial Cardiac Simulator for the Study and Advancement of Left Atrial Appendage Occlusion.
Cardiovasc Eng Technol
January 2025
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, MA, Cambridge, USA.
Purpose: Atrial fibrillation (AF) is the most common chronic cardiac arrhythmia that increases the risk of stroke, primarily due to thrombus formation in the left atrial appendage (LAA). Left atrial appendage occlusion (LAAO) devices offer an alternative to oral anticoagulation for stroke prevention. However, the complex and variable anatomy of the LAA presents significant challenges to device design and deployment.
View Article and Find Full Text PDFIntroduction: The infarcted heart is energetically compromised exhibiting a deficient production of adenosine triphosphate (ATP) and the ensuing impaired contractile function. Short-term blockade of the protein S100A9 improves cardiac performance in mice after myocardial infarction (MI). The implications upon ATP production during this process are not known.
View Article and Find Full Text PDFAnemia and Prognosis in Patients with Acute Venous Thromboembolism.
Thromb Haemost
January 2025
Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Background: Studies found an association between anemia and overall mortality and major bleeding (MB) in patients with acute venous thromboembolism (VTE), but whether anemia is causally related to death, bleeding, or recurrent VTE is uncertain.
Objectives: To explore the association between anemia at baseline and short-/long-term clinical outcomes in a prospective cohort of 928 patients with acute VTE.
Methods: We defined anemia as a hemoglobin <13 g/dL for men/< 12 g/dL for women.
Electrophysiological correlates of selective speech adaptation.
Brain Lang
January 2025
Department of Cognitive Neuropsychology, Tilburg University, Tilburg, the Netherlands.
Selective speech adaptation refers to the phenomenon where repeated exposure to identical speech sounds temporarily reduces sensitivity to that sound. We used EEG to track the time-course of this effect. Participants were first exposed to the Dutch vowels /e/ or /ø/ and subsequently identified ambiguous sounds halfway between these phonemes.
View Article and Find Full Text PDFEnhancing brain tumor surgery precision with multimodal connectome imaging: Structural and functional connectivity in language-dominant areas.
Clin Neurol Neurosurg
January 2025
Department of Neurosurgery, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, USA.
Objectives: Language is a critical aspect of human cognition and function, and its preservation is a priority for neurosurgical interventions in the left frontal operculum. However, identification of language areas can be inconsistent, even with electrical mapping. The use of multimodal structural and functional neuroimaging in conjunction with intraoperative neuromonitoring may augment cortical language area identification to guide the resection of left frontal opercular lesions.
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