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Sphingosine-1-Phosphate, a Marker of Endothelial Injury and Disease Severity in Preeclampsia.
Hypertension
January 2025
Division of Obstetrics and Gynecology, Institute of Clinical Sciences Lund, Lund University, Sweden. (C.E., F.P., L.E., S.R.H.).
Background: Preeclampsia is a hypertensive pregnancy disorder marked by endothelial damage. Healthy endothelium is covered by a protective glycocalyx layer, which, when degraded, releases detectable products into the blood. Sphingosine-1-phosphate (S1P) is a cardiovascular biomarker involved in glycocalyx preservation, linked to placentation and preeclampsia development.
View Article and Find Full Text PDFExploring microfluidics-based organoid interactions through analysis of albumin secretion.
Lab Chip
January 2025
State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, #2 Linggong Road, Dalian, 116024, China.
Organoids-on-a-chip exhibit significant potential for advancing disease modeling, drug screening, and precision medicine, largely due to their capacity to facilitate interactions among organoids. However, the influence of chip design on these interactions remains poorly understood, primarily due to our limited knowledge of the mediators of communication and the complexity of interaction dynamics. This study demonstrates that analyzing albumin secretion from liver organoids within an organoids-on-a-chip system can provide a measure of the interaction intensity among organoids, offering valuable insights into how chip design influences these interactions.
View Article and Find Full Text PDFMeasuring high-efficiency perfect composite vortex beams with reflective metasurfaces in microwave band.
Nanophotonics
January 2025
Departments of Optics and General Physics, Francisk Skorina Gomel State University, Sovetskaya Str. 104, Gomel 246019, Belarus.
Optical vortex beams carrying orbit angular momentum have attracted significant attention recently. Perfect vortex beams, characterized by their topological charge-independent intensity profile, have important applications in enhancing communication capacity and optimizing particle manipulation. In this paper, metal-insulator-metal copper-coin type reflective metasurfaces are proposed to generate perfect composite vortex beams in X-band.
View Article and Find Full Text PDFStepwise reduction of an asymmetric π-expanded pyracylene towards the crystalline radical trianion.
Chem Sci
January 2025
Department of Chemistry, University at Albany, State University of New York Albany New York 12222 USA
The chemical reduction of a pyracylene-hexa--hexabenzocoronene-(HBC)-fused nanographene TPP was investigated with K and Rb metals to reveal its multi-electron acceptor abilities. The reaction of TPP with the above alkali metals, monitored by UV-vis-NIR and H NMR spectroscopy, evidenced the stepwise reduction process. The use of different solvents and secondary ligands enabled isolation of single crystals of three different reduced states of TPP with 1, 2, and 3 electrons added to its π-system.
View Article and Find Full Text PDFPhosphorus-solubilizing fungi promote the growth of P. Y. Li by regulating physiological and biochemical reactions and protecting enzyme system-related gene expression.
Front Genet
January 2025
Chongqing Engineering Laboratory of Green Planting and Deep Processing of Famous-Region Drug in the Three Gorges Reservoir Region, College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.
Introduction: P. Y. Li is a plant used to treat respiratory diseases such as pneumonia, bronchitis, and influenza.
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