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A qualitative exploration of illness-related experiences, emotions, and coping among adults with postural orthostatic tachycardia syndrome (POTS).
J Health Psychol
January 2025
Vanderbilt University Medical Center, Nashville, TN, USA.
Postural orthostatic tachycardia syndrome (POTS) is a relatively common, burdensome condition of the autonomic nervous system characterized by orthostatic intolerance. This paper presents a subset of findings from a qualitative study investigating the lived experience and perspectives of adults with POTS. Twenty-nine individuals participated in a series of focus groups.
View Article and Find Full Text PDFEffect of two novel GABAA receptor positive allosteric modulators on neuropathic and inflammatory pain in mice.
Neuropharmacology
January 2025
Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China. Electronic address:
Loss of GABAergic inhibition in the spinal dorsal horn (SDH) is implicated in central sensitization and chronic pain. Both agonists and positive allosteric modulators (PAMs) of GABAA receptor are found to be effective in the management of chronic pain. In addition to benzodiazepines, neuroactive steroids (NASs) also act as PAMs through binding to unique sites of GABAA receptors.
View Article and Find Full Text PDFPublic perceptions of brain health in young and middle-aged adults in Cuba: Opportunities for intervention.
Neuroscience
January 2025
Faculty of Psychology, Potinficia Universidad Católica del Ecuador, Ecuador. Electronic address:
Understanding brain health is increasingly important, particularly in light of growing public health challenges related to neurological and psychiatric conditions. These include the rising prevalence of mental health disorders, such as depression and anxiety, as well as neurodegenerative diseases like Alzheimer's and Parkinson's. Lifestyle factors, including stress, poor diet, and insufficient physical activity, also significantly impact cognitive function.
View Article and Find Full Text PDFPlasma biomarkers of endothelial function in people with depressive disorder: A systematic review and meta-analysis.
J Affect Disord
January 2025
Postgraduate Program in Psychiatry and Mental Health, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Postgraduate Program in Movement Sciences and Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil; Faculty of Health Sciences, Universidad Autónoma de Chile, Providencia, Chile.
The objective of this study is to conduct a literature review and summarize existing research comparing levels of blood markers of endothelial function in people with depression with controls. We searched major databases (Embase, PubMed, Web of Science, and PsycINFO) from inception to 23.07.
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