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Surgical management of thymic tumors: a narrative review with focus on robotic-assisted surgery.
Mediastinum
November 2024
University of Bern, Bern, Switzerland.
Background And Objective: Thymic epithelial tumors, including thymomas and thymic carcinomas, represent the most common mediastinal tumors and account for up to 50% of all anterior mediastinal tumors. For early stages of these thymic tumors, complete resection of the entire thymus is the recommended treatment. The transition from open surgery to video-assisted thoracoscopic surgery (VATS) and recently to robotic-assisted thoracic surgery (RATS) has fundamentally altered the treatment of thymic tumors.
View Article and Find Full Text PDFTwo Hundred Nanometer Thin Multifocal Graphene Oxide Metalens for Varying Magnification Broadband Imaging.
ACS Nano
December 2024
Nanophotonics Research Center, Institute of Microscale Optoelectronics and State Key Laboratory of Radio Frequency Heterogeneous, Shenzhen University, Shenzhen 518060, China.
Conventional microscopes, which rely on multiple objective lenses for varying magnifications, are bulky, complex, and costly, making them difficult to integrate into compact devices. They require frequent manual adjustments, complicating the imaging process and increasing maintenance burdens. This paper explores the potential of single ultrathin graphene metalens to address this issue.
View Article and Find Full Text PDFDual-Enhanced SERS Satellite Immuno-Nanocomplex for Multiple PSA-Mediated PHI Assay Toward Clinical Prostate Cancer Screening.
Adv Sci (Weinh)
December 2024
Institute for Safflower Industry Research, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization (Ministry of Education), School of Pharmacy, Shihezi University, Shihezi, 832003, China.
Prostate specific antigen (PSA) is widely used in liquid biopsy of prostate cancer (PCa) but still faces challenges due to the poor specificity. Herein, this study reports a double-SERS satellite immunoassay, made of an Au-Ag dealloyed intra-nanogap nanoflower (Au-Ag DINF) with strong SERS signals and Au magnetic nanoparticles (AuMNPs) with magnetic capture and SERS amplification, for sensing multiple PSA (free PSA (fPSA), complexed PSA (cPSA) and [-2]proPSA (p2PSA)) toward potential PCa screening. Unlike the previous studies focus on the tPSA and fPSA/tPSA ratio (f/t PSA%), this work introduces a multiple PSA-mediated Prostate Health Index (PHI) assay with significantly increased the predictive accuracy and specificity of PCa, especially the patients with a tPSA level in the "diagnostic gray zone".
View Article and Find Full Text PDFFor lensless ghost imaging (GI) with thermal light, the axially relative motion constrained in the range of the system's depth of focus (DOF) can still cause image blurring because of a variable magnification. We propose a motion-deblurring GI system with pseudo-thermal light, which can overcome the resolution degradation caused by the axial motion. Both the analytical and experimental results demonstrate that high-resolution GI can be always obtained as long as the target's random motion range is smaller than the system's DOF, without using the prior information of motion estimation.
View Article and Find Full Text PDFExploring the connectivity of dorsolateral prefrontal cortex and the modulatory impact of transcranial magnetic stimulation in adolescents with depression: a focus on pain-related cognitive processing.
BMC Psychiatry
November 2024
Department of Psychiatry, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan, 030001, China.
Article Synopsis
- The study investigates the role of the dorsolateral prefrontal cortex (DLPFC) in pain cognition among adolescents with depression, revealing abnormal cognitive responses to pain linked to this brain region.
- Using neuroimaging data, the research compared functional connectivity (FC) of DLPFC in depressed adolescents to a control group and analyzed the effects of transcranial magnetic stimulation (TMS) versus sertraline treatment.
- Results showed specific FC patterns correlated with pain perception and reduced pain-related thoughts after TMS treatment, suggesting that DLPFC is crucial in linking cognitive control and pain processing in affected adolescents.
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