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The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer.

Int Rev Cell Mol Biol

January 2025

Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India. Electronic address:

In preclinical studies, bioactive phytochemicals have shown enormous potential therapeutic efficacy against various human malignancies. These natural compounds have been shown to possess an inherent potential to alter the molecular signaling pathways and epigenetic modulatory activity involved in multiple physiological functions. Recently, epigenetic therapy has emerged as an important therapeutic modality due to the reversible nature of epigenetic alterations.

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Leveraging Epigenetic Alterations in Pancreatic Ductal Adenocarcinoma for Clinical Applications.

Semin Cancer Biol

January 2025

Biomedical Research Center, Slovak Academy of Sciences, Dubravska Cesta 9, 84505 Bratislava, Slovakia. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by late detection and poor prognosis. Recent research highlights the pivotal role of epigenetic alter- ations in driving PDAC development and progression. These changes, in conjunction with genetic mutations, contribute to the intricate molecular landscape of the disease.

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Antimicrobial Activity of UV-Activated and Cysteamine-Grafted Polymer Foils Against Bacteria and Algae.

Polymers (Basel)

January 2025

Centre for Nanomaterials and Biotechnology, Faculty of Science, University of Jan Evangelista Purkyně, Pasteurova 15, 400 96 Ústí nad Labem, Czech Republic.

Surface modification of various polymer foils was achieved by UV activation and chemical grafting with cysteamine to improve surface properties and antimicrobial efficacy. UVC activation at 254 nm led to changes in surface wettability and charge density, which allowed the introduction of amino and thiol functional groups by cysteamine grafting. X-ray photoelectron spectroscopy (XPS) confirmed increased nitrogen and sulfur content on the modified surfaces.

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This research follows the principles of circular economy through the zero waste concept and cascade approach performed in two steps. Our paper focuses on the first step and explores the characteristics of developed biocomposite materials made from a biodegradable poly(lactic acid) polymer (PLA) reinforced with natural fibers isolated from the second generation of biomass (agricultural biomass and weeds). Two plants, L.

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Due to the high viscosity and low fluidity of viscous crude oil, how to effectively recover spilled crude oil is still a major global challenge. Although solar thermal absorbers have made significant progress in accelerating oil recovery, its practical application is largely restricted by the variability of solar radiation intensity, which is influenced by external environmental factors. To address this issue, this study created a new composite fiber that not only possesses solar energy conversion and storage capabilities but also facilitates crude oil removal.

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