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Research progress on antitumor effects of sea buckthorn, a traditional Chinese medicine homologous to food and medicine.
Front Nutr
July 2024
Traditional Chinese Medicine College, Ningxia Medical University, Yinchuan, Ningxia, China.
Sea buckthorn (), as a homologous species of medicine and food, is widely used by Mongolians and Tibetans for its anti-tumor, antioxidant and liver-protecting properties. In this review, the excellent anti-tumor effect of sea buckthorn was first found through network pharmacology, and its active components such as isorhamnetin, quercetin, gallic acid and protocatechuic acid were found to have significant anti-tumor effects. The research progress and application prospect of sea buckthorn and its active components in anti-tumor types, mechanism of action, liver protection, anti-radiation and toxicology were reviewed, providing theoretical basis for the development of sea buckthorn products in the field of anti-tumor research and clinical application.
View Article and Find Full Text PDFGlycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis.
Eur J Pharmacol
March 2024
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address:
Glycyrrhizic acid (GA), one of the major active components derived from licorice root, exerts liver-protecting activity. Its molecular mechanisms of action, however, remain not completely understood. The angiotensin (Ang) converting enzyme (ACE) 2/Ang-(1-7)/Mas axis, regulated by ACE2 through converting Ang II into Ang-(1-7) to activate Mas receptor, counteracts the pro-inflammatory and pro-steatotic effects of the ACE/Ang II/Ang II receptor type 1 (AT1) axis.
View Article and Find Full Text PDF[Chemical constituents of Lindera aggregata and their bioactivities: a review].
Zhongguo Zhong Yao Za Zhi
November 2023
School of Pharmacy, Jiangxi University of Chinese Medicine Nanchang 330004, China.
Article Synopsis
- * Its extracts have shown multiple health benefits, such as anti-tumor, anti-inflammatory, liver-protecting, antioxidant, and glucose-lowering effects.
- * This study reviews the research on the chemical properties and bioactivities of L. aggregata over the last decade, aiming to guide future research and use of this plant.
Proteomics and network pharmacology of Ganshu Nuodan capsules in the prevention of alcoholic liver disease.
Front Endocrinol (Lausanne)
October 2023
Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Introduction: Ganshu Nuodan is a liver-protecting dietary supplement composed of () spore powder, (Lour.) Merr. (), Bunge () and (Fisch.
View Article and Find Full Text PDFCKCC1913 mediated modulation of the gut-liver axis alleviated insulin resistance and liver damage induced by type 2 diabetes.
Food Funct
September 2023
Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School of Food Science and Engineering, Hainan University, Haikou 570228, China.
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by dysregulation of lipid metabolism, insulin resistance, and gut microbiota disorder. Compared to drug interventions, probiotic interventions may have a more enduring effect without producing any side effects. Thus, the potential of probiotics as a therapeutic approach for diabetes and other metabolic disorders has gained increasing attention in recent years.
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