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Functional characterization of eQTLs and asthma risk loci with scATAC-seq across immune cell types and contexts.
Am J Hum Genet
January 2025
Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA; Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA. Electronic address:
cis-regulatory elements (CREs) control gene transcription dynamics across cell types and in response to the environment. In asthma, multiple immune cell types play an important role in the inflammatory process. Genetic variants in CREs can also affect gene expression response dynamics and contribute to asthma risk.
View Article and Find Full Text PDFBaicalein tethers CD274/PD-L1 for autophagic degradation to boost antitumor immunity.
Autophagy
December 2024
Institute of Energy Metabolism and Health, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Immune checkpoint inhibitors, especially those targeting CD274/PD-L1yield powerful clinical therapeutic efficacy. Thoughmuch progress has been made in the development of antibody-basedCD274 drugs, chemical compounds applied for CD274degradation remain largely unavailable. Herein,baicalein, a monomer of traditional Chinese medicine, isscreened and validated to target CD274 and induces itsmacroautophagic/autophagic degradation.
View Article and Find Full Text PDFAn accurate IDMS-based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean.
J Food Sci
January 2025
Key Laboratory of Specialty Agri-Product Quality and Hazard Controlling Technology of Zhejiang, College of Life Sciences, China Jiliang University, Hangzhou, P.R. China.
Phytohemagglutinin (PHA), a natural tetramer comprising PHA-E and PHA-L subunits that preferentially bind to red and white blood cells, respectively, constitutes a significant antinutritional and allergenic factor in common bean seeds. The accurate measurement of PHA content is a prerequisite for ensuring food safety inspections and facilitating genetic improvements in common bean cultivars with reduced PHA levels. Currently, mainstream methods for PHA quantification involve hemagglutination assays and immunodetection, but these methods often require fresh animal blood and lack specificity and accuracy.
View Article and Find Full Text PDFInfluence of Biological Sex and Congenital Iron Deficiency on Neonatal Cytokine Responses.
Nutrients
December 2024
Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Background/objectives: Stimulated cord blood mononuclear cell (CBMC) cytokine responses were previously shown to predict the risk of childhood atopic disease. Iron deficiency (ID) at birth may also program atopic disease. Males are at a higher risk of pediatric atopic disease, but it is not known whether congenital ID impacts CBMC immune responses differentially by sex.
View Article and Find Full Text PDFThe new gamma interferon (IFN-γ) algorithm for tuberculosis diagnosis in cynomolgus macaques.
PLoS One
December 2024
Office of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tuberculosis (TB) is the first infectious disease to be screened-out from specified pathogen-free cynomolgus macaques (Macaca fascicularis; Mf) using in human pharmaceutical testing. Being in either latent or active stage after exposure to the Mycobacterium tuberculosis complex (MTBC), the monkey gamma-interferon release assay (mIGRA) was previously introduced for early TB detection. However, a notable incidence of indeterminate results was observed.
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