AI Article Synopsis
- Prior to 1971, adenosis and primary adenocarcinoma of the vagina were rare, but since then, cases have surged linked to maternal use of Diethylstibestrol (DES) during pregnancy, causing issues for female offspring.
- There are over 170 reported cases of adenocarcinoma, while it's estimated that up to one million women may have adenosis.
- Treatment options vary, with benign adenosis being controversial and adenocarcinoma typically treated with surgery, radiation, or both; four patients showed complete remission after treatment with either approach.
Article Abstract
Prior to 1971, adenosis and primary adenocarcinoma of the vagina were unusual entities. Since then, a marked increase in both processes has occurred, felt to be related to maternal ingestion of Diethylstibestrol (DES) and other estrogenic compounds during the first trimester, with subsequent abnormalities in female offspring. To date, there are over 170 cases of adenocarcinoma reported, and there may be as many as one million patients with adenosis. Treatment of benign adenosis is somewhat of a controversy but adenocarcinoma is treated with surgery radiation or a combination thereof, depending upon the specifics of the patients. Four patients are presented, one treated surgically and three with radiotherapy, all with complete remission over one to two years. It behooves all phys-cians caring for young women to be aware of these disease processes for the maximum therapeutic benefit to be achieved.
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| http://dx.doi.org/10.1016/0090-8258(74)90061-4 | DOI Listing |
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