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Modelling Cellular Response to Ionizing Radiation: Mechanistic, Semi-Mechanistic, and Phenomenological Approaches - A Historical Perspective.
Radiat Res
August 2024
Department of Physiology, Anatomy and Genetics (DPAG) Oxford University, Oxford, OX1 3PT, United Kingdom.
Radiation research is a multidisciplinary field, and among its many branches, mathematical and computational modelers have played a significant role in advancing boundaries of knowledge. A fundamental contribution is modelling cellular response to ionizing radiation as that is the key to not only understanding how radiation can kill cancer cells, but also cause cancer and other health issues. The invention of microdosimetry in the 1950s by Harold Rossi paved the way for brilliant scientists to study the mechanism of radiation at cellular and sub-cellular scales.
View Article and Find Full Text PDFPalladium-Mediated -Arylation of Cysteine Residues with 4-[F]Fluoroiodobenzene ([F]FIB).
Bioconjug Chem
February 2024
Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Transition-metal-mediated bioconjugation chemistry has been used extensively to design and synthesize molecular probes to visualize, characterize, and quantify biological processes within intact living organisms at the cellular and subcellular levels. We demonstrate the development and validation of chemoselective [F]fluoro-arylation chemistry of cysteine residues using Pd-mediated -arylation chemistry with 4-[F]fluoroiodobenzene ([F]FIB) as an aryl electrophile. The novel bioconjugation technique proceeded in excellent radiochemical yields of 73-96% within 15 min under ambient and aqueous reaction mixture conditions, representing a versatile novel tool for decorating peptides and peptidomimetics with short-lived positron emitter F.
View Article and Find Full Text PDFLINC00886 Facilitates Hepatocellular Carcinoma Tumorigenesis by Sequestering microRNA-409-3p and microRNA-214-5p.
J Hepatocell Carcinoma
June 2023
Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University & Hebei Provincial Key Laboratory of Liver Fibrosis in Chronic Liver Diseases, Shijiazhuang, Hebei, 050051, People's Republic of China.
Purpose: As the major subtype of liver cancer, hepatocellular carcinoma (HCC) suffers from high mortality and is prone to recurrence. Long non-coding RNAs (lncRNAs) are well characterized to be pivotal players contributing to HCC pathogenesis and progression. Therefore, this study intended to probe the biological functions of LINC00886 in hepatocarcinogenesis.
View Article and Find Full Text PDFBioinformatics Analysis to Uncover the Potential Drug Targets Responsible for Peptidoglycan and Lysine Biosynthesis.
Bioinform Biol Insights
May 2023
Department of Pharmacy, Faculty of Health Science, Universitas Muhammadiyah Mataram, Mataram, Indonesia.
Drug-resistant tuberculosis (TB), which results mainly from the selection of naturally resistant strains of (MTB) due to mismanaged treatment, poses a severe challenge to the global control of TB. Therefore, screening novel and unique drug targets against this pathogen is urgently needed. The metabolic pathways of and MTB were compared using the Kyoto Encyclopedia of Genes and Genomes tool, and further, the proteins that are involved in the metabolic pathways of MTB were subtracted and proceeded to protein-protein interaction network analysis, subcellular localization, drug ability testing, and gene ontology.
View Article and Find Full Text PDFStimuli-responsive drug delivery systems triggered by intracellular or subcellular microenvironments.
Adv Drug Deliv Rev
May 2023
Key Laboratory of Smart Drug Delivery (Ministry of Education), Minhang Hospital, State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, PR China. Electronic address:
Drug delivery systems (DDS) triggered by local microenvironment represents the state-of-art of nanomedicine design, where the triggering hallmarks at intracellular and subcellular levels could be employed to exquisitely recognize the diseased sites, reduce side effects, and expand the therapeutic window by precisely tailoring the drug-release kinetics. Though with impressive progress, the DDS design functioning at microcosmic levels is fully challenging and underexploited. Here, we provide an overview describing the recent advances on stimuli-responsive DDSs triggered by intracellular or subcellular microenvironments.
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