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Early prediction of post-pancreatectomy acute pancreatitis after pancreaticoduodenectomy based on serum C-reactive protein.
Pancreatology
January 2025
Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Background: Post-pancreatectomy acute pancreatitis (PPAP) is an early acute inflammatory process of the pancreatic remnant that is associated with a series of downstream pancreas-specific complications. This study aimed to investigate the relationship between postoperative serum C-reactive protein (CRP) levels and the occurrence of PPAP after pancreaticoduodenectomy (PD).
Methods: Consecutive patients who underwent PD between January 1, 2020, and May 31, 2022, were retrospectively analyzed.
Clinical and Financial Validation of the International Study Group for Pancreatic Surgery (ISGPS) Definition of Post-Pancreatectomy Acute Pancreatitis (PPAP): International Multicenter Prospective Study.
Ann Surg
October 2024
Hepatopancreatobiliary and Liver Transplant Surgery, Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Padua, Italy.
Objective: To validate the ISGPS definition and grading system of PPAP after pancreatoduodenectomy (PD).
Summary Background Data: In 2022, the International Study Group for Pancreatic Surgery (ISGPS) defined post-pancreatectomy acute pancreatitis (PPAP) and recommended a prospective validation of its diagnostic criteria and grading system.
Methods: This was a prospective, international, multicenter study including patients undergoing PD at 17 referral pancreatic centers across Europe, Asia, Oceania, and the United States.
Preoperative hyperamylasemia relates to renal dysfunction and hyperamylasemia in cardiac surgery: an observational study.
Heart Vessels
October 2024
Departments of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-ku, Hamamatsu, Shizuoka, 431-3192, Japan.
The role of preoperative hyperamylasemia in the perioperative enzyme levels in patients undergoing cardiac surgery is unclear. The primary outcome of this observational clinical study was to determine whether patients with preoperative hyperamylasemia undergoing on-pump cardiac surgery document an increase in serum amylase levels perioperatively compared with patients with normal serum amylase levels preoperatively. This prospective study evaluated serum total, pancreatic, and salivary amylase levels, estimated glomerular filtration rate (eGFR), and serum creatinine before the operation at postoperative days (POD) 1, 2, 3, and 7.
View Article and Find Full Text PDFReal-world evidence comparing early and late pancreatic stent placement to prevent post-ERCP pancreatitis.
Endosc Int Open
October 2024
Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Article Synopsis
- Pancreatic stenting is effective in reducing the occurrence and severity of post-ERCP pancreatitis (PEP), but optimal timing for placement is not well studied.
- A study analyzed 590 patients to compare early pancreatic stent placement (EPSP) with late placement (LPSP), finding that EPSP significantly lowers PEP rates (2.9% vs. 7.3%) and hyperamylasemia (19.7% vs. 27.8%).
- Results support the practice of placing pancreatic stents immediately before or after endoscopic procedures to minimize pancreatitis risk.
Hyperlipasemia in the immediate postoperative period predicts postoperative pancreatic fistula after pancreatic resections.
Surgery
December 2024
Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany. Electronic address:
Background: Postoperative pancreatic fistula is the most common severe complication after pancreatic surgery. It associated with increased morbidity and prolonged hospital stay. Identifying patients at low risk for postoperative pancreatic fistula is essential to enable timely removal of drains and facilitate early discharge.
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