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EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction.
Nat Commun
January 2025
Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China.
Myelomatous bone disease is a complication characterized by lytic bone lesions, reduced bone formation, bone pain, and increased fracture risk. Understanding these underlying mechanisms is crucial for developing effective therapeutic approaches. Here we show the role of enhancer of zeste homolog 2 (EZH2) in bone lesions induced by myeloma cells.
View Article and Find Full Text PDFMulti-omics analysis of placental metabolomics and transcriptomics datasets reveals comprehensive insights into the pathophysiology of preeclampsia.
J Pharm Biomed Anal
January 2025
Reproductive Sciences & Advanced Bioinformatics Application & Research Center, Inonu University, Malatya, Türkiye; Department of Biomedical Engineering, Faculty of Engineering, Inonu University, Malatya, Türkiye. Electronic address:
Preeclampsia, a life-threatening pregnancy complication, remains a major global health concern. Understanding the complex molecular mechanisms underlying this disorder is crucial for improving both diagnostics and therapeutic strategies. In this study, a multi-omics approach based on NMR metabolomics and RNA-seq transcriptomics analyses was conducted to analyze placental tissue samples obtained from patients with preeclampsia and healthy controls.
View Article and Find Full Text PDFIdentification of Primary Metabolites in H NMR-Based Metabolomics of Plants.
Methods Mol Biol
January 2025
Natural Products Lab, Institute of Biology, Leiden University, Leiden, The Netherlands.
Identifying metabolites in NMR-based plant metabolomics is challenging due to the complexity of plant metabolites. This complexity stems from the abundance and diverse chemical properties of compounds, which vary in concentration across plant specimens. Additionally, the lack of automated identification software complicates the analysis process.
View Article and Find Full Text PDFTetrafocal Bone Lengthening by Ilizarov Frame Application in a Patient With Segmental Tibial Bone Loss: A Case Report.
JBJS Case Connect
January 2025
Department of Surgery, The Aga Khan University, Karachi, Pakistan.
Case: Thirty-five-year-old man presented with 14 cm segmental tibial defect after crush injury (Gustilo Anderson type-IIIA). Tetrafocal bone transport using Ilizarov frame was performed with 3 osteotomies. Two minor complications-skin invagination and failure at proximal docking site-were addressed.
View Article and Find Full Text PDFMidshaft Clavicle Fracture With Acute Vascular Injury and Complete Brachial Plexus Palsy: A Case Report Type of Study.
JBJS Case Connect
January 2025
Department of Orthopedic Surgery, Albany Medical Center, Albany, New York.
Case: We present the case of a 24-year-old woman who sustained a left midshaft clavicle fracture with acute subclavian artery compression, subclavian vein laceration, and complete brachial plexus palsy after a motor vehicle collision. The patient underwent urgent open reduction internal fixation of the clavicle and repair of the subclavian vein. Two years later, she underwent opponensplasty and flexor digitorum profundus tendon transfers.
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