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Trans-Placental Transfer Mechanisms of Aromatic Amine Antioxidants (AAs) and -Phenylenediamine Quinones (PPD-Qs): Evidence from Human Gestation Exposure and the Rat Uterine Perfusion Model.
Environ Sci Technol
December 2024
MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.
Aromatic amine antioxidants (AAs), as rubber additives, and their ozone photochemical oxidation products of -phenylenediamine quinone (PPD-Qs) have attracted great attention recently due to their wide environmental occurrences and toxicity. However, there is currently no research on the exposure risks during pregnancy and their trans-placental transfer mechanisms. Herein, 20 AAs and six PPD-Qs were analyzed in 60 maternal urine and fifty-six amniotic fluid samples ( = 53 pairs).
View Article and Find Full Text PDFTargeted lipid nanoparticles to prevent trans-placental passage in the ex vivo human placental cotyledon perfusion model.
Drug Deliv Transl Res
October 2024
Department of Obstetrics, Wilhemina Children's Hospital, UMC Utrecht, Utrecht, The Netherlands.
Medication use during pregnancy poses risks to both the mother and the fetus. These risks include an elevated potential for fetotoxicity due to placental drug transport. Nanomedicines offer a promising solution by potentially preventing trans-placental passage.
View Article and Find Full Text PDFA genetically small fetus impairs placental adaptations near term.
Dis Model Mech
August 2024
Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge CB2 0SW, UK.
The placenta is a gatekeeper between the mother and fetus, adapting its structure and functions to support optimal fetal growth. Studies exploring adaptations of placentae that support the development of genetically small fetuses are lacking. Here, using a mouse model of impaired fetal growth, achieved by deleting insulin-like growth factor 2 (Igf2) in the epiblast, we assessed placental nutrient transfer and umbilical artery (UA) blood flow during late gestation.
View Article and Find Full Text PDFmodeling for placenta perfusion of nicotine.
Front Pharmacol
April 2024
Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy, Yokohama, Kanagawa, Japan.
Nicotine readily crosses the placenta to reach fetuses. However, membrane transporters, e.g.
View Article and Find Full Text PDFABCB1 expression is increased in human first trimester placenta from pregnant women classified as overweight or obese.
Sci Rep
March 2023
Department of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, 8000, Aarhus C, Denmark.
Obesity has become a global health challenge also affecting reproductive health. In pregnant women, obesity increases the risk of complications such as preterm birth, macrosomia, gestational diabetes, and preeclampsia. Moreover, obesity is associated with long-term adverse effects for the offspring, including increased risk of cardiovascular and metabolic diseases and neurodevelopmental difficulties.
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