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A case of mucormycosis caused by Rhizopus microsporus in a renal transplant patient.

CEN Case Rep

January 2025

Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital, 2-2-2, Toranomon, Minato, Tokyo, Japan.

A 54-year-old man who had been on the kidney donor register for 32 years received a kidney from a 9-year-old boy who had died of fulminant myocarditis. The post-operative course was poor, and hemodialysis was still needed after surgery. A kidney biopsy one hour after surgery showed a neutrophil-predominant inflammatory cell infiltrate localized to the peritubular capillaries (PTC) and acute tubular necrosis of the proximal tubule.

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Background: High-risk pulmonary embolism (PE) is associated with significant mortality. Thrombolysis is the therapy of choice, while interventional thrombectomy may be a helpful strategy in case of contraindications or failed thrombolysis. However, the procedure may be complicated by catheter-induced embolization of clots and/or haemodynamic compromise.

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Fat embolism syndrome (FES) occurs when fat droplets from bone marrow or adipose tissue enter the circulation due to bone fractures or surgical interventions. It typically develops 12 to 72 hours after injury. However, fulminant FES, characterized by its rapid onset, is rare and can rapidly progress to a life-threatening condition.

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Article Synopsis
  • An 84-year-old woman with a past medical history of hypertension, diabetes, and hypothyroidism presented with a rapidly growing thigh mass, which was diagnosed as high-grade leiomyosarcoma that doubled in size within two weeks.
  • Following surgery and initiation of radiotherapy, she developed complications including respiratory distress and heart failure due to extensive metastatic disease and a pulmonary embolism.
  • The case emphasizes the difficulties in treating aggressive sarcomas in frail patients and suggests that earlier intervention with chemotherapy might have led to better outcomes, highlighting the importance of careful patient evaluation for cancer treatment options.
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Article Synopsis
  • * In a case study, fetal distress—specifically bradycardia—was observed before any maternal symptoms, indicating that fetal complications can occur independently of the mother's health.
  • * The patient, a 34-year-old woman at full term, experienced seizures and cardiac arrest during an emergency cesarean delivery for fetal distress, leading to immediate interventions, stabilization, and recovery in the surgical intensive care unit.
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