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Purpose: To propose a domain-conditioned and temporal-guided diffusion modeling method, termed dynamic Diffusion Modeling (dDiMo), for accelerated dynamic MRI reconstruction, enabling diffusion process to characterize spatiotemporal information for time-resolved multi-coil Cartesian and non-Cartesian data.
Methods: The dDiMo framework integrates temporal information from time-resolved dimensions, allowing for the concurrent capture of intra-frame spatial features and inter-frame temporal dynamics in diffusion modeling. It employs additional spatiotemporal ($x$-$t$) and self-consistent frequency-temporal ($k$-$t$) priors to guide the diffusion process.
Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies.
Sci Rep
January 2025
Instituto do Coração (InCor), Faculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
Doxorubicin-induced cardiomyopathy (DOX-IC) is a significant and common complication in patients undergoing chemotherapy, leading to cardiac remodeling and reduced heart function. We hypothesized that the intrapericardial injection of hydrogels derived from the cardiac decellularized extracellular matrix (dECM) loaded with adipose tissue-derived stromal cells (ASC) and their secretome dampens or reverses the progression of DOX-IC. DOX-IC was induced in Wistar male rats through ten weekly intra-peritoneal injections of doxorubicin (cumulative dose: 18 mg/kg).
View Article and Find Full Text PDFSpatiotemporal metabolic mapping of ex-situ preserved hearts subjected to dialysis by integration of bio-SPME sampling with non-targeted metabolipidomic profiling.
Anal Chim Acta
February 2025
Department of Chemistry, University of Waterloo, Waterloo, ON, Canada. Electronic address:
Background: Normothermic ex situ heart perfusion (ESHP) has emerged as a valid modality for advanced cardiac allograft preservation and conditioning prior to transplantation though myocardial function declines gradually during ESHP thus limiting its potential for expanding the donor pool. Recently, the utilization of dialysis has been shown to preserve myocardial and coronary vasomotor function. Herein, we sought to determine the changes in myocardial metabolism that could support this improvement.
View Article and Find Full Text PDFEffects of Caffeine Intake Combined with Self-Selected Music During Warm-Up on Anaerobic Performance: A Randomized, Double-Blind, Crossover Study.
Nutrients
January 2025
School of Sport Science, Beijing Sport University, Beijing 100084, China.
Background: Both listening to music during warm-up and consuming caffeine before exercise have been independently shown to enhance athletic performance. However, the potential synergistic effects of combining these strategies remain largely unexplored. To date, only two studies have reported additional benefits to combining music during warm-up with a caffeine dose of 3 mg/kg on taekwondo-specific performance tasks.
View Article and Find Full Text PDFThe Effects of CrossFit Practice on Physical Fitness and Overall Quality of Life.
Int J Environ Res Public Health
December 2024
Centre of Research, Education, Innovation and Intervention in Sport and Porto Biomechanics Laboratory, Faculty of Sport, University of Porto, 4200-450 Porto, Portugal.
We have examined the impact of CrossFit workout sessions on physical fitness, comparing the obtained outcomes with the recommendations of the American College of Sports Medicine. In addition, we provide suggestions to improve training monitoring, as well as practical applications for researchers, coaches and practitioners. CrossFit imposes high cardiorespiratory and metabolic demands, promoting improvements in circulatory capacity, oxidative metabolism and muscular endurance.
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