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Information-Distilled Generative Label-Free Morphological Profiling Encodes Cellular Heterogeneity.
Adv Sci (Weinh)
August 2024
Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, 000000, Hong Kong.
Image-based cytometry faces challenges due to technical variations arising from different experimental batches and conditions, such as differences in instrument configurations or image acquisition protocols, impeding genuine biological interpretation of cell morphology. Existing solutions, often necessitating extensive pre-existing data knowledge or control samples across batches, have proved limited, especially with complex cell image data. To overcome this, "Cyto-Morphology Adversarial Distillation" (CytoMAD), a self-supervised multi-task learning strategy that distills biologically relevant cellular morphological information from batch variations, is introduced to enable integrated analysis across multiple data batches without complex data assumptions or extensive manual annotation.
View Article and Find Full Text PDFRole of scrape cytology smear preparation in the diagnosis of ovarian masses-utility and pitfalls.
Diagn Cytopathol
October 2023
Department of Obstetric and Gynecology, Hind Institute of Medical Sciences, Barabanki, India.
Background: Scrape cytology technique is useful for rapid intraoperative diagnosis of ovarian mass lesions that acts as an adjunct to frozen section examination. Though ovaries can be accessed by laparoscopy and USG guided FNAC, there are controversial reports regarding the safety of these procedures. The present study has been designed to evaluate the role of scrape cytology in a variety of ovarian mass lesions.
View Article and Find Full Text PDFSynthesis of silver nanoparticles employing leaf extract and their antifungal activity against phytopathogen.
Biochem Biophys Rep
September 2022
Department of Botany, Mohanlal Sukhadia University, Udaipur, Rajasthan, India.
The mediated silver (PL-AgNPs) nanoparticles are very stable and efficient. UV-Vis spectroscopy, dynamic light scattering (DLS), X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM), and energy dispersive X-ray spectroscopy (EDX) were used to characterize the produced AgNPs. UV-Vis analysis showed a characteristic peak at 435 nm corresponding to surface plasmon resonance.
View Article and Find Full Text PDFCyto-morphological features of parathyroid lesions: Fine-needle aspiration cytology series from an endocrine tumor referral center.
Diagn Cytopathol
February 2022
Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Background: Descriptions of parathyroid cell cyto-morphology are limited. Fine-needle aspiration cytology (FNAC) with immunocytochemistry (ICC) or biochemical PTH measurements may help verify the parathyroid origin in extraordinary cases, although these methods are nowadays largely replaced by imaging techniques.
Methods: We collected all available FNAC reports of parathyroid lesions from our department spanning 20 years, to characterize the clinical use of parathyroid FNAC, and to assess morphological correlates between cytology and subsequent histopathology.
Aluminium stress causes plant growth retardation and engenders productivity loss under acidic soil conditions. This study accentuates morpho-physiological and molecular bases of aluminium (Al) tolerance within and between wild (ILWL-15) and cultivated (L-4602 and BM-4) lentil species. Morpho-physiological studies revealed better cyto-morphology of tolerant genotypes over sensitive under Al stress conditions.
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