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Background: Treatment of latent tuberculosis infection (LTBI) is essential for refugee patients who have been relocated to the United States to prevent progression to active infection.
Objective: This study aimed to determine the effectiveness of a multidisciplinary team approach, embedded within a primary care clinic, to treatment of LTBI in newly resettled refugee patients compared with a local health department.
Methods: This was a single-center, retrospective chart review of newly resettled refugee patients 18-89 years old with a diagnosis of LTBI.
Child Migrants in Family Detention in the US: Addressing Fragmented Care.
Children (Basel)
August 2024
Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital, Harvard Medical School, 125 Nashua St. Suite 725, Boston, MA 02114, USA.
Article Synopsis
- Migrant children in detention face poor living conditions and fragmented medical care due to frequent relocations, highlighting the need for better medical documentation.
- A study of 165 medical records from a family detention center showed significant gaps in documentation for acute care, follow-up recommendations, and vaccination history.
- Improved documentation practices are essential to prevent errors in diagnosis and ensure that all detained children receive appropriate healthcare regardless of their immigration status.
BCG infection dose guides dendritic cell migration and T cell priming in the draining lymph node.
Scand J Immunol
March 2024
Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.
In contrast to delayed-type hypersensitivity (DTH) and other hallmark reactions of cell-mediated immunity that correlate with vaccine-mediated protection against Mycobacterium tuberculosis, the contribution of vaccine dose on responses that emerge early after infection in the skin with Bacille Calmette-Guérin (BCG) is not well understood. We used a mouse model of BCG skin infection to study the effect of BCG dose on the relocation of skin Dendritic cells (DCs) to draining lymph node (DLN). Mycobacterium antigen 85B-specific CD4 P25 T cell-receptor transgenic (P25 TCRTg) cells were used to probe priming to BCG in DLN.
View Article and Find Full Text PDFIsoniazid preventive therapy completion and factors associated with non-completion among patients on antiretroviral therapy at Kisenyi Health Centre IV, Kampala, Uganda.
PLoS One
August 2023
Department of Disease Control and Environmental Health, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.
Background: Isoniazid preventive therapy (IPT) is given to HIV patients to reduce the risk of active tuberculosis (TB). However, treatment completion remains suboptimal among those that are initiated. This study aimed to determine the completion level of IPT and the factors associated with non-completion among patients on antiretroviral therapy (ART) at Kisenyi Health Center IV in Kampala, Uganda.
View Article and Find Full Text PDFCoping with drug resistant tuberculosis alongside COVID-19 and other stressors in Zimbabwe: A qualitative study.
PLOS Glob Public Health
August 2023
Faculty of Public Health and Policy, Department of Global Health and Development, LSHTM, London, United Kingdom.
Households in low-resource settings are more vulnerable to events which adversely affect their livelihoods, including shocks e.g. death of family members, droughts and more recently COVID-19.
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