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Exposure to Leishmania spp. and sand flies in domestic animals in northwestern Ethiopia.
Parasit Vectors
July 2015
School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot, 76100, Israel.
Background: Human visceral leishmaniasis caused by Leishmania donovani is considered an anthroponosis; however, Leishmania-infected animals have been increasingly reported in L. donovani foci, and the role of these animals as reservoirs for human L. donovani infection remains unclear.
View Article and Find Full Text PDFAntibodies to the core proteins of Nairobi sheep disease virus/Ganjam virus reveal details of the distribution of the proteins in infected cells and tissues.
PLoS One
January 2016
The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey GU24 0NF, United Kingdom.
Nairobi sheep disease virus (NSDV; also called Ganjam virus in India) is a bunyavirus of the genus Nairovirus. It causes a haemorrhagic gastroenteritis in sheep and goats with mortality up to 90%. The virus is closely related to the human pathogen Crimean-Congo haemorrhagic fever virus (CCHFV).
View Article and Find Full Text PDFRole of anti-L-selectin antibody in burn and smoke inhalation injury in sheep.
Am J Physiol Lung Cell Mol Physiol
November 2002
Department of Anesthesiology, The University of Texas Medical Branch, Texas 77555-0833, USA.
We hypothesized that the antibody neutralization of L-selectin would decrease the pulmonary abnormalities characteristic of burn and smoke inhalation injury. Three groups of sheep (n = 18) were prepared and randomized: the LAM-(1-3) group (n = 6) was injected intravenously with 1 mg/kg of leukocyte adhesion molecule (LAM)-(1-3) (mouse monoclonal antibody against L-selectin) 1 h after the injury, the control group (n = 6) was not injured or treated, and the nontreatment group (n = 6) was injured but not treated. All animals were mechanically ventilated during the 48-h experimental period.
View Article and Find Full Text PDFAntibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton.
J Immunol
April 2001
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA.
L-Selectin mediates leukocyte rolling on endothelium and immobilized leukocytes. Its regulation has been the subject of much study, and the conformation of the molecule may play an important role in its function. Here we report that a conformational change in L-selectin, induced by an anti-lectin domain mAb (LAM1-116) and recognized by another mAb directed to a conserved epitope on L-selectin (EL-246), predisposed L-selectin to cytoskeletal association.
View Article and Find Full Text PDFEffects of protein kinase and phosphatase inhibitors and anti-L antisera on K+ transport in LK sheep red cells.
Bioelectrochemistry
December 2000
Department of Veterinary Preclinical Sciences, University of Liverpool, UK.
We investigated the role of protein phosphorylation in the action of anti-L on low potassium (LK) sheep red cells. Anti-L stimulated the Na/K pump by four- to fivefold, but Na/K pump activity in anti-L-stimulated or in control cells was unaffected by protein kinase/protein phosphatase (PK/PP) inhibitors. KCl co-transport activity was inhibited by anti-L (about 50%).
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