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Characterization, Bio-Prospection, and Comparative Metagenomics of Bacterial Communities Revealing the Predictive Functionalities in Wild and Cultured Samples of Industrially Important Red Seaweed Gracilaria dura.
Curr Microbiol
January 2025
Applied Phycology and Biotechnology Division, CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, 364001, India.
The present study explores the microbial community associated with the industrially important red seaweed Gracilaria dura to determine the diversity and biotechnological potential through culture and metagenomics approaches. In the first part of the investigation, we isolated and characterized 75 bacterial morphotypes, with varied colony characteristics and metabolic diversity from the wild seaweed. Phylogenetic analysis identified isolates in Proteobacteria, Firmicutes, and Actinobacteria, with Bacillus sp.
View Article and Find Full Text PDFImpact of HPMCAS Grade on the Release of Weakly Basic Drugs from Amorphous Solid Dispersions.
Mol Pharm
January 2025
Department of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Oppositely charged species can form electrostatic interactions in aqueous solution, and these may lead to reduced solubility of the interacting components. Herein, insoluble complex formation between the lipophilic weakly basic drugs, cinnarizine or loratadine, and the enteric polymer, hydroxypropyl methylcellulose acetate succinate (HPMCAS), was studied and used to better understand drug and polymer release from their corresponding amorphous solid dispersions (ASDs). Surface area normalized release experiments were performed at various pH conditions for three different grades of HPMCAS, LF, MF and HF, as well as their ASDs.
View Article and Find Full Text PDFInfluence of polymer and surfactant-based precipitation inhibitors on supersaturation-driven absorption of Ibrutinib from high-dose lipid-based formulations.
Int J Pharm
January 2025
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab, India. Electronic address:
There is a growing pharmaceutical interest in supersaturated lipid-based formulations (Super-LbF) as an innovative strategy to enhance drug loading capacities while simultaneously reducing pill burden. This approach involves increasing the drug concentration above its equilibrium solubility in a lipid solution, achieved through temperature-induced supersaturation or the dissolution of lipophilic ionic salts. However, the physical instability and potential drug precipitation upon the dispersion of LbF remain critical.
View Article and Find Full Text PDFSolution-mediated phase transformation of cocrystals at the solid-liquid interface: Relationships between the supersaturation generation rate and transformation pathway.
Int J Pharm
January 2025
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, Department of Pharmaceutical Engineering, China Pharmaceutical University, Nanjing 211198, China. Electronic address:
Cocrystals easily undergo solution-mediated phase transformation at the surface of dissolving cocrystals during dissolution, which significantly deteriorates the solubility advantage of cocrystals. Here, a new scenario for the phase transformation of liquiritigenin (LQ) cocrystals in which the boundary of phase transformation diffuses along the surface to the bulk of the cocrystal was identified. Additionally, depending on the rate of supersaturation generation, phase transformation processes to the anhydrate and hydrate of LQ compete during cocrystal dissolution.
View Article and Find Full Text PDFIs beudantite a stable host phase of arsenic and lead? New insights from molecular-scale kinetic analyses.
J Hazard Mater
December 2024
Faculty of Science and Engineering, Southern Cross University, Lismore, NSW 2480, Australia.
Article Synopsis
- Beudantite is a secondary mineral formed from the oxidation of sulfide-rich mining tailings, impacting the geochemical cycling of arsenic (As) and lead (Pb) at mine sites.
- Research showed that when beudantite dissolves under varying pH conditions (2-8), it releases small amounts of As and Pb, with the release rate changing over time.
- The study concludes that beudantite is a stable host for As and Pb, potentially reducing environmental and health risks by immobilizing these metals released from mining activities.
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