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Equivalence of freeze-dried and liquid-frozen formulations of MVA-BN as smallpox and mpox vaccine.
Hum Vaccin Immunother
December 2024
Executive Management, Bavarian Nordic A/S, Hellerup, Denmark.
Modified Vaccinia Ankara Bavarian Nordic (MVA-BN) as a smallpox and mpox vaccine has been approved in its liquid-frozen (LF) formulation in the US, Canada, and EU. A freeze-dried (FD) formulation may offer additional benefits, such as a longer shelf life and reduced dependence on cold chain storage and transport. In a phase 2 clinical trial, 651 vaccinia-naïve participants were vaccinated with two doses of MVA-BN LF or FD, 4 weeks apart.
View Article and Find Full Text PDFVaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters.
PLoS One
September 2021
Molecular and Cell Biology, Taiwan International Graduate Program, National Defense Medical Center, Academia Sinica and Graduate Institute of Life Science, Taipei, Taiwan.
COVID-19 in humans is caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that belongs to the beta family of coronaviruses. SARS-CoV-2 causes severe respiratory illness in 10-15% of infected individuals and mortality in 2-3%. Vaccines are urgently needed to prevent infection and to contain viral spread.
View Article and Find Full Text PDFHuman Antibody Responses Following Vaccinia Immunization Using Protein Microarrays and Correlation With Cell-Mediated Immunity and Antibody-Dependent Cellular Cytotoxicity Responses.
J Infect Dis
October 2021
Emmes, Rockville, Maryland, USA.
Article Synopsis
- The study investigates the immunological responses to the modified vaccinia Ankara (MVA) smallpox vaccine using 523 participants who received either lyophilized or liquid MVA in different administration methods.
- Results showed that MVA triggered significant antibody production against several viral proteins, particularly after 28 and 42 days, with strong correlations between some antibody responses and plaque reduction neutralization tests (PRNT).
- The findings suggest that specific proteins from the MVA vaccine could be potential indicators of protection and may inform future vaccine development strategies.
Chronicle of a consolidated success: smallpox eradication policies in Brazil (1962-1973).
Salud Colect
August 2019
Estudiante de Doctorado, Programa de Pós-Graduación en Ciências Sociais, Instituto de Filosofia y Ciências Humanas, Universidade Estadual de Campinas, San Pablo, Brasil.
The aim of this article is to understand actions taken towards smallpox eradication in Brazil, in the framework of the Smallpox Eradication campaign that took place in the 1960s and 1970s. The article argues that, in addition to the bifurcated needle and the lyophilized vaccine, epidemiological surveillance - based on the construction of instruments and protocols for health surveillance - was the third key element that guaranteed the eradication of the disease. The hypothesis is that the actions taken towards the control and eradication of smallpox contributed to the construction of new health institutions within Brazil.
View Article and Find Full Text PDFFreeze-dried live attenuated smallpox vaccine prepared in cell culture "LC16-KAKETSUKEN": Post-marketing surveillance study on safety and efficacy compliant with Good Clinical Practice.
Vaccine
November 2015
Chiba University, 1-33, Yayoicho, Inage Ward, Chiba-shi, Chiba 263-8522, Japan.
Background: In Japan, production of smallpox vaccine LC16m8 (named LC16-KAKETSUKEN) was restarted and was determined to be maintained as a national stockpile in March 2002.
Objective: To conduct a post-marketing surveillance study of the vaccination of freeze-dried live attenuated smallpox vaccine prepared in cell culture LC16-KAKETSUKEN using attenuated vaccinia strain LC16m8. The study complied with Good Clinical Practice, focusing on a comparison between primary vaccinees and re-vaccinees.
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