Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The Mouse Papillomavirus Epigenetic Signature Is Characterised by DNA Hypermethylation after Lesion Regression.
Viruses
October 2021
Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand.
Article Synopsis
- - Papillomaviruses (PVs), particularly human papillomavirus (HPV), are linked to skin cancers like cutaneous squamous cell carcinoma (cSCC), although HPV DNA isn't always found in tumors, and DNA methylation may play a role in cancer development.
- - In a study using a mouse model (MmuPV1), researchers looked at how DNA methylation changes after PV infection by comparing lesions in immunosuppressed mice, some of which spontaneously regressed after stopping immunosuppression.
- - The analysis found 834 hypermethylated DNA fragments in regressed lesions, particularly in genes related to cancer, while actively infected lesions showed no methylation changes, suggesting hypermethylation
Actinic, or solar, keratosis is caused by chronic ultraviolet-induced damage to the epidermis. In the UK, 15-23% of individuals have actinic keratosis lesions. Risk factors include: advanced age; male gender; cumulative sun exposure or phototherapy; Fitzpatrick skin phototypes I-II; long-term immuno-suppression and genetic syndromes e.
View Article and Find Full Text PDFUric acid, an important antioxidant contributing to survival in termites.
PLoS One
September 2017
Department of Applied Bioresources Chemistry, The United Graduate School of Agriculture, Tottori University, 4-101 Koyamacho-minami, Tottori, Japan.
Reactive oxygen species (ROS) are generated spontaneously in all organisms and cause oxidative damage to biomolecules when present in excess. Accumulated oxidative damage accelerates aging; enhanced antioxidant capacity may be a positive factor for longevity. Recently, numerous studies of aging and longevity have been performed using short-lived animals, however, longevity mechanisms remain unknown.
View Article and Find Full Text PDFNear-infrared and ultraviolet induced isomerization of crotonic acid in N2 and Xe cryomatrices: first observation of two high-energy trans C-O conformers and mechanistic insights.
J Chem Phys
December 2014
CQC, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
E-crotonic acid was isolated in cryogenic solid N2 and xenon matrices, and subjected to Laser ultraviolet (UV) and near-infrared (NIR) irradiations. In the deposited matrices, the two low-energy cis C-O E-cc and E-ct conformers, which are the only forms significantly populated in the gas phase, were observed. UV irradiation (λ= 250 nm) of the compound in N2 matrix allows for experimental detection, not just of the two low-energy cis C-O isomers of Z-crotonic acid previously observed in the experiments carried out in argon matrix [Z-cc and Z-ct; R.
View Article and Find Full Text PDFTemplating sub-10 nm atomic layer deposited oxide nanostructures on graphene via one-dimensional organic self-assembled monolayers.
Nano Lett
September 2014
Department of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208, United States.
Molecular-scale control over the integration of disparate materials on graphene is a critical step in the development of graphene-based electronics and sensors. Here, we report that self-assembled monolayers of 10,12-pentacosadiynoic acid (PCDA) on epitaxial graphene can be used to template the reaction and directed growth of atomic layer deposited (ALD) oxide nanostructures with sub-10 nm lateral resolution. PCDA spontaneously assembles into well-ordered domains consisting of one-dimensional molecular chains that coat the entire graphene surface in a manner consistent with the symmetry of the underlying graphene lattice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!