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Rare diseases: a challenge in paediatric dentistry.
Eur J Paediatr Dent
September 2024
Director of the Postgraduate School of Paediatric Dentistry, University of Pisa.
Article Synopsis
- - Rare diseases, though infrequent (happening in 100-500 per million), pose significant challenges in pediatric dentistry due to their complex needs and the required specialized care.
- - Conditions like X-linked hypophosphatemic rickets (XLH), hypophosphatasia (HPP), and osteogenesis imperfecta (OI) show how systemic health problems can directly affect oral health, necessitating a multidisciplinary approach for effective treatment.
- - XLH is particularly notable, caused by mutations in the PHEX gene, leading to issues such as poor enamel mineralization, dental abscesses, and unique dental manifestations, emphasizing the crucial role dentists play in early diagnosis and referrals to genetic specialists.
Seizures due to pyridoxine deficiency in Parkinson's disease.
Seizure
May 2024
Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:
Article Synopsis
- * A review highlights the connection between PD, new-onset seizures, and pyridoxine deficiency, using case reports that show seizures often occur with high-dose dopaminergic therapy and underlying vitamin deficiencies, despite other tests returning normal results.
- * The study emphasizes the importance of monitoring pyridoxine levels in PD patients, particularly those experiencing dietary issues or undergoing significant medication changes, to improve patient care and quality of life by potentially reducing seizure risks.
Development of tight junction-strengthening compounds using a high-throughput screening system to evaluate cell surface-localized claudin-1 in keratinocytes.
Sci Rep
February 2024
Research and Development Headquarters, Well-Being Research Laboratories, Lion Corporation, 100 Tajima, Odawara, Kanagawa, 256-0811, Japan.
Tight junctions (TJs) are important factors constituting the physical barriers of the skin, and their suppression has been described in various conditions, such as aged skin and atopic dermatitis lesions. However, the methods for improving skin TJ function remain insufficient. Therefore, to obtain compounds that can improve TJ function, we developed a novel high-throughput screening system termed live-cell immunostaining to evaluate cell surface-localized claudin-1 (CLDN1) with high selectivity using normal human epidermal keratinocytes (NHEKs).
View Article and Find Full Text PDFAssessing pyridoxine adjuvant therapy effects on blood glucose levels in type 2 diabetes: A randomized clinical trial.
J Med Life
October 2023
Department of Medicine, College of Medicine, Maysan University, Maysan, Iraq.
Pyridoxal-5-phosphate (PLP) is the bioactive derivative of vitamin B6, functioning as a coenzyme in over 150 metabolic pathways. Insufficient PLP levels could be associated with the onset and progression of diabetes. This study aimed to assess the effects of pyridoxine adjuvant treatment on blood glucose levels in patients with type 2 diabetes mellitus (T2DM).
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