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Therapy Side Effects in Systemic Lupus Erythematosus.
Curr Health Sci J
July 2018
Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.
Glucosteroids (GS) are widely used drugs for various inflammatory pathologies (Nephrotic syndrome, Proliferative glomerulonephritis, Extramembrane glomerulonephritis, Nephropathy of the Nodous Poliarterita (PAN), Nephropathy from purple Henoch-Schonlein, lupus nephropathy (LN), Acute adrenal insufficiency Waterhouse-Friederichsen, Chronic adrenal insufficiency Addison, Systemic Lupus Erythematosus (SLE), Polymyositis and dermatomyositis, Chronic granulomatosis, Crohn's disease, Hemorrhagic rectocolitis, Hemolytic anemias, Acute leukemias and chronic lymphocytic leukemia, Hodgkin's lymphoma). Although they are prescribed for their anti-inflammatory and immunosuppressive properties, they also have many side effects, hyperglycemia being one of the most common and representative, which is why these drugs need careful monitoring when administered over the long term. This paper presents the case of a 39 year old patient diagnosed with systemic lupus erythematosus (SLE) with class IV lupus nephropathy (LN) who developed numerous complications due to the pathogenic side effects: diabetes, amenorrhea, recurrent infections, and depression.
View Article and Find Full Text PDF[Intraorbital extraocular Langerhans' cell granuloma: primary surgical approach. Why? - case report].
Arq Bras Oftalmol
November 2009
We present a case in which a patient with intraorbital Langerhans' cell granuloma, with anatomical and functional skills compromised by intraorbital hypertension, which was treated with urgency orbitotomy by cranial approach. Male, two years-old, presented conjuntival proptosis, red eye, complete ophthalmoplegy, exophthalmos, with non-fotoreactive mydriasis and blepharoptosis of the right eye. Fundoscopy presented venous enlargement with optic disc edema.
View Article and Find Full Text PDF[Interleukin 10 in disseminated lupus erythematosus].
J Soc Biol
August 2002
Service de Médecine Interne et d'Immunologie Clinique, Hôpital Béclère, Institut Paris-Sud sur les Cytokines, Clamart.
A number of years ago several groups reported that Interleukin 10 (IL10) was vigorously overproduced in disseminated lupus erythematosus (reviewed in Llorente et al., 2000). This hyperproduction obeys two different patterns.
View Article and Find Full Text PDF[Disseminated strongyloidiasis].
Presse Med
April 2001
Service de Parasitologie et Mycologie, CHU Pitié Salpêtrière, Paris.
ENDEMIC ZONES: Strongyloidiasis is an intestinal parasitosis which is frequently found in tropical and subtropical regions. RISK: The "autoinfection" cycle during this helminthiasis explains why the infection can be perpetuated without further exposure to exogenous, infective larvae. Hyperinfection may occur by dissemination of Strongyloides stercoralis in immuno-compromised patients, particularly those under corticotherapy.
View Article and Find Full Text PDFA retrospective study on the treatment and evolution of Graves' ophthalmopathy.
Rom J Endocrinol
November 1993
C. I. Parhon Institute of Endocrinology, Bucharest, Romania.
Although Graves' ophthalmopathy (GO) seems to be unanimously considered as an autoimmune disease, its pathogenesis is still unknown. That is why the different therapeutical formulas led to ambiguous results. We think that a critical retrospective analysis on our therapeutical possibilities in GO will help us to become aware of our limits in treating this pathology.
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