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Graphene oxide aggregate-assisted LDI-MS for the direct analysis of triacylglycerol in complex biological samples.
Anal Chim Acta
December 2018
Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address:
Knowledge of blood triacylglycerol (TAG) species is essential to clarify the physiological functions of individual TAG molecules and also to develop potential biomarkers for related diseases. Commonly, lipid samples prepared by organic liquid-liquid extraction contain complex components, thus cannot be directly characterized by mass spectrometry (MS) and often require an additional purification step. Here, we described a laser desorption ionization - mass spectrometry (LDI-MS) method that utilized aggregated graphene oxide (AGO) as both lipid extractant and MS matrix (AGOLDI-MS), to characterize and quantify plasma TAG species without the use of harmful solvent or complex separation step.
View Article and Find Full Text PDFXanthoma-like Skin Changes in an Elderly Woman with a Normal Lipid Profile.
Acta Dermatovenerol Croat
July 2017
Professor Joanna Maj, MD, PhD, Department and Clinic of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chałubińskiego 1, PL-50-368 Wrocław, Poland;
Dear Editor, An 83-year-old woman developed yellow-brownish infiltrates, nodules, and tumors mimicking xanthomas, mostly involving the periorbital and chest area within three months (Figure 1). She had no abnormalities in serum cholesterol or triglycerides levels. A detailed laboratory analysis revealed the presence of mild monoclonal gammopathy with a presence of immunoglobulin G (IgG) kappa light chains; however, according to hematologist consultation, it did not require medical intervention.
View Article and Find Full Text PDFContinuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice.
Phytomedicine
March 2011
Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, IISPV, Universitat Rovira i Virgili, Reus, Spain.
The incidence of obesity and related metabolic diseases is increasing globally. Current medical treatments often fail to halt the progress of such disturbances, and plant-derived polyphenols are increasingly being investigated as a possible way to provide safe and effective complementary therapy. Rooibos (Aspalathus linearis) is a rich source of polyphenols without caloric and/or stimulant components.
View Article and Find Full Text PDF[Acute hyperlipemic pancreatitis (2 cases)].
Tunis Med
July 2007
Service de chirurgie générale, EPS Habib Bourguiba, Sfax, Tunisie.
Unlabelled: THE AIM of this work was to study the clinical and therapeutic features of this affection.
Case Report: Our retrospective study concerned two cases of hyperlipemic pancreatitis treated during 6 years from 1998 to 2003. The incidence of this affection was 1.
Role of ageing and coronary atherosclerosis in the development of cardiac fibrosis in the rabbit.
Cardiovasc Res
December 2004
Department of Biopathology and Image Diagnostics, Anatomic Pathology Institute, Tor Vergata University of Rome, Via della Ricerca Scientifica, 00133 Rome, Italy.
Objective: Myocardial fibrosis contributes to the impairing of cardiac function and characterizes ageing, but is also a consequence of atherosclerotic ischemic disease. Since atherosclerosis is a slow progressive disease, which prevails in elderly populations, the aim of this study was to distinguish the contribution of ageing and atherosclerosis to cardiac fibrosis.
Methods: Coronary atherosclerosis was induced in 5-6-year-old rabbits by a hyperlipemic diet for 9 months.
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