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Variable positive end-expiratory pressure in an experimental model of acute respiratory distress syndrome: an advanced ventilation modality.
BJA Open
September 2024
Unit for Anaesthesiological Investigations, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine, University of Geneva, Geneva, Switzerland.
Background: Introducing variability in tidal volume, ventilatory frequency, or both is beneficial during mechanical ventilation in acute respiratory distress syndrome (ARDS). We investigated whether applying cycle-by-cycle variability in the positive end-expiratory pressure (PEEP) exerts beneficial effect on lung function in a model of ARDS.
Methods: Rabbits with lung injury were randomly allocated to receive mechanical ventilation for 6 h by applying a pressure-controlled mode with constant PEEP of 7 cm HO (PC group: =6) or variable PEEP (VEEP) with a coefficient of variation of 21.
Benefits of intratracheal and extrathoracic high-frequency percussive ventilation in a model of capnoperitoneum.
J Appl Physiol (1985)
April 2024
Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.
Abdominal inflation with CO is used to facilitate laparoscopic surgeries, however, providing adequate mechanical ventilation in this scenario is of major importance during anesthesia management. We characterized high-frequency percussive ventilation (HFPV) in protecting from the gas exchange and respiratory mechanical impairments during capnoperitoneum. In addition, we aimed to assess the difference between conventional pressure-controlled mechanical ventilation (CMV) and HFPV modalities generating the high-frequency signal intratracheally (HFPVi) or extrathoracally (HFPVe).
View Article and Find Full Text PDFChanges in lung mechanics and ventilation-perfusion match: comparison of pulmonary air- and thromboembolism in rats.
BMC Pulm Med
January 2024
Department of Medical Physics and Informatics, University of Szeged, 9 Korányi fasor, Szeged, H-6720, Hungary.
Background: Pulmonary air embolism (AE) and thromboembolism lead to severe ventilation-perfusion defects. The spatial distribution of pulmonary perfusion dysfunctions differs substantially in the two pulmonary embolism pathologies, and the effects on respiratory mechanics, gas exchange, and ventilation-perfusion match have not been compared within a study. Therefore, we compared changes in indices reflecting airway and respiratory tissue mechanics, gas exchange, and capnography when pulmonary embolism was induced by venous injection of air as a model of gas embolism or by clamping the main pulmonary artery to mimic severe thromboembolism.
View Article and Find Full Text PDFArterial versus end-tidal carbon dioxide levels in children with congenital heart disease: a prospective cohort study in patients undergoing pulmonary catheterization.
Ann Med Surg (Lond)
July 2023
Department of Anesthesiology, Children's Medical Center, Tehran University of Medical Sciences.
Unlabelled: Capnography has been the standard in the operating room for a long time now. When variable amounts of intrapulmonary shunt and intracardiac shunt are taken into account, arterial carbon dioxide (CO) and end-tidal CO typically match rather well. The gap between arterial and end-tidal CO widens in patients with cardiopulmonary disorders.
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