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Intestinal Carnitine Status and Fatty Acid Oxidation in Response to Clofibrate and Medium-Chain Triglyceride Supplementation in Newborn Pigs.
Int J Mol Sci
March 2023
Laboratory of Developmental Nutrition, Department of Animal Sciences, North Carolina State University, Raleigh, NC 27695, USA.
To investigate the role of peroxisome proliferator-activated receptor alpha (PPARα) in carnitine status and intestinal fatty acid oxidation in neonates, a total of 72 suckled newborn piglets were assigned into 8 dietary treatments following a 2 (±0.35% clofibrate) × 4 (diets with: succinate+glycerol (Succ), tri-valerate (TC5), tri-hexanoate (TC6), or tri-2-methylpentanoate (TMPA)) factorial design. All pigs received experimental milk diets with isocaloric energy for 5 days.
View Article and Find Full Text PDFHomologous repair deficiency-associated genes in invasive breast cancer revealed by WGCNA co-expression network analysis and genetic perturbation similarity analysis.
Cell Cycle
May 2023
Department of General surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: Homologous repair deficiency (HRD) causes double-strand break repair to be impeded, which is a common driver of carcinogenesis. However, the therapeutic and prognostic potential of HRD in invasive breast cancer (BRCA) has not been fully explored using comprehensive bioinformatics analysis.
Materials And Methods: HRD score was defined as the unweighted sum of LOH, TAI, and LST scores and obtained from the previous study according to Theo A et al.
Organocatalytic Synthesis of Phenols from Diaryliodonium Salts with Water under Metal-Free Conditions.
Org Lett
July 2022
Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
The metal-free synthesis of phenols from diaryliodonium salts with water was developed by using -benzylpyridin-2-one as an organocatalyst. In this process, sterically congested, functionalized, and heterocycle-containing iodonium salts were smoothly converted to the desired products, and the clofibrate and mecloqualone derivatives were also synthesized in high yields. In addition, the gram-scale experiment was successfully carried out with 10 mmol of a sterically congested substrate.
View Article and Find Full Text PDFModelling of the adsorption of pharmaceutically active compounds on carbon-based nanomaterials.
J Hazard Mater
July 2021
Ruđer Bošković Institute, Bijenička cesta 54, Zagreb 10000, Croatia. Electronic address:
Understanding and acquiring knowledge about the adsorption of pharmaceuticals on carbon-based nanomaterials (CNMs) is imperative to the chemical engineering applications of CNMs, as well as to risk assessment and pollution control of both CNMs and pharmaceuticals. A computational assessment of the mechanism and thermodynamics of the adsorption of 18 most common pharmaceuticals (acetaminophen, acetylsalicylic acid, atenolol, caffeine, carbamazepine, clofibric acid, diclofenac, fenofibric acid, fluoxetine, gemfibrozil, ibuprofen, ketoprofen, naproxen, phenazone, primidone, propranolol, salicylic acid, tramadol) on four different CNMs (pristine/functionalised graphene and carbon nanotube) in two different solvents (water and n-octanol) was provided. We show that the adsorption of pharmaceuticals on pristine CNMs is controlled by dispersion forces, π-interactions and hydrophobic interaction.
View Article and Find Full Text PDFTransport of organic solutes in ion-exchange membranes: Mechanisms and influence of solvent ionic composition.
Water Res
February 2021
Particle and Interfacial Technology Group, Ghent University, Belgium; KWR Water Research Institute, Netherlands. Electronic address:
Ion-exchange membrane (IEM)-based processes are used in the industry or in the drinking water production to achieve selective separation. The transport mechanisms of organic solutes/micropollutants (i.e.
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