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NIR-I emissive cyanine derived molecular probe for selective monitoring of hepatic albumin levels during hyperglycemia.
J Mater Chem B
May 2024
School of Chemical Sciences, Indian Institute of Technology Mandi, Kamand-175005, Himachal Pradesh, India.
Article Synopsis
- The study introduces BI-CyG, a small molecule optical marker designed through structural modifications of a cyanine scaffold, offering improved excitation and emission wavelengths compared to existing probes.
- The probe emits in the near-infrared (NIR) region and shows selective binding to serum albumin, demonstrating its potential for imaging and diagnostic applications in conditions like hyperglycemia.
- Molecular modeling and experimental studies confirm the probe's performance and its ability to track changes in albumin levels in hepatic cells, alongside insights into the therapeutic role of metformin in managing hyperglycemia-induced albumin alterations.
Quantification of circulating alpha-1-antitrypsin polymers associated with different genotypes.
Clin Chem Lab Med
September 2024
Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, 9297University of Brescia, Brescia, Italy.
Objectives: Alpha-1-antitrypsin deficiency is a genetic disorder caused by mutations in the gene encoding alpha-1-antitrypsin (AAT), the major serine protease inhibitor in plasma. Reduced AAT levels are associated with elevated risk of developing emphysema mainly due to uncontrolled activity of neutrophil elastase in the lungs. The prevalent Z-AAT mutant and many rare pathogenic AAT variants also predispose to liver disease due to their accumulation as polymeric chains in hepatocytes.
View Article and Find Full Text PDFReply to: "Hepatic encephalopathy and survival after transjugular intra-hepatic portosystemic shunt: Do spontaneous portosystemic shunts matter?".
J Hepatol
June 2024
Department of Experimental and Clinical Medicine, University of Florence, Italy.
Associations of Combined Lifestyle Factors with MAFLD and the Specific Subtypes in Middle-Aged and Elderly Adults: The Dongfeng-Tongji Cohort Study.
Nutrients
October 2023
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, China.
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the crucial pathogenesis for intra-hepatic and extra-hepatic diseases, especially in elderly adults. Lifestyle management may be a modifiable cost-effective measure for MAFLD prevention, but the evidence is limited. A total of 23,408 middle-aged and elderly individuals were included in a longitudinal study from 2008 to 2018.
View Article and Find Full Text PDFPredictive and Diagnostic Value of Serum Adipokines in Pregnant Women with Intrahepatic Cholestasis.
Int J Environ Res Public Health
February 2022
Department of Obstetrics and Gynecology, Veris delli Ponti Hospital, 73020 Lecce, Italy.
The objective of this study was to assess the value of serum leptin, adiponectin, apelin, and ghrelin as biomarkers for the prediction and diagnosis of intra-hepatic cholestasis (ICP). This prospective study included pregnant women in the third trimester of pregnancy: 63 with ICP, 48 and 15 of whom had mild and severe disease, respectively, and 32 as controls. ICP women had increased median levels of serum leptin, adiponectin, apelin, and ghrelin compared to the controls ( < 0.
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