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Practice Patterns for Acute Asthma Exacerbation in Adult Patients Admitted to U.S. Intensive Care Units.
Ann Am Thorac Soc
October 2024
Pulmonary Center, Department of Medicine, Chobanian & Avedisian School of Medicine, Boston University, Boston, Massachusetts.
Guidelines recommend systemic corticosteroids and inhaled β-agonists for patients with severe asthma exacerbation who are admitted to intensive care units. The benefits and utilization of adjunct treatments after guideline-recommended first-line treatments have been initiated are unclear. Examine practice patterns of adjunct interventions in US intensive care units (ICUs) and their associations with outcomes for adults with severe asthma exacerbations.
View Article and Find Full Text PDFEffect of Humidified High-Flow Nasal Cannula Oxygen Therapy with a Pulmonary Infection Control Window as a Ventilation Switching Indication in Combination with Atomizing Inhalation of Terbutaline on the Lung Function of Patients with Acute Exacerbation of COPD.
Acta Med Okayama
June 2024
Department of Respiratory and Critical Care Medicine, Tiantai Hospital of Traditional Chinese Medicine.
We investigated how humidified high-flow nasal cannula oxygen therapy (HFNC) with a pulmonary infection control (PIC) window as a ventilation switching indication in combination with atomizing inhalation of terbutaline affects the lung function of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We examined 140 hospitalized AECOPD patients randomized to control and observation groups. Conventional supportive therapy and invasive mechanical ventilation with tracheal intubation were conducted in both groups, with a PIC window as the indication for ventilation switching.
View Article and Find Full Text PDFUtilizing the drug repurposing strategy on current drugs: new leads for peptic ulcers biochemical and biomolecular dynamics studies.
J Biomol Struct Dyn
January 2024
Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman.
The hyperactivity of urease enzymes plays a crucial role in the development of hepatic coma, hepatic encephalopathy, urolithiasis, gastric and peptic ulcers. Additionally, these enzymes adversely impact the soil's nitrogen efficiency for crop production. In the current study 100 known drugs were tested against Jack Bean urease and urease and identified three inhibitors i.
View Article and Find Full Text PDFRivastigmine-Bambuterol Hybrids as Selective Butyrylcholinesterase Inhibitors.
Molecules
December 2023
Post-Doctoral Innovation Site, Jinan University Affiliation, Yuanzhi Health-Tech Inc., Hengqin District, Zhuhai 519000, China.
Selective butyrylcholinesterase inhibitors are considered promising drug candidates for the treatment of Alzheimer's disease. In this work, one rivastigmine-bambuterol hybrid (MTR-1) and fourteen of its analogues were synthesized, purified, and characterized. In vitro cholinesterase assays showed that all the compounds were more potent inhibitors of BChE when compared to AChE.
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