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A cross-sectional study of associations between the C-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy.
Am J Clin Nutr
December 2024
Rutgers Global Health Institute, Department of Biostatistics and Epidemiology, School of Public Health, Rutgers, the State University of New Jersey, New Brunswick, NJ, United States. Electronic address:
Article Synopsis
- Environmental enteropathy (EE) is a condition affecting children in low-resource settings due to exposure to enteric pathogens, and a new noninvasive breath test (C-SBT) to assess carbohydrate digestion was developed and validated.
- The study aimed to link the C-SBT results to the lactulose/rhamnose ratio (LR) and identify their relationship with child growth, as well as investigate connections with socio-economic factors, dietary diversity, and other EE biomarkers.
- Results indicated variability in C-SBT and LR measurements across different sites, with some associations found between child growth and test timing, but no significant links between C-SBT and LR or overall growth metrics were established.
The sucrose challenge symptoms test optimized for diagnosis of congenital sucrase isomaltase deficiency.
PLoS One
September 2024
QOL Medical LLC, Vero Beach, Florida, United States of America.
Background: Congenital sucrase isomaltase deficiency (CSID), an inherited carbohydrate malabsorption disorder, is difficult to diagnose because of overlapping symptoms with other gastrointestinal (GI) diseases. An at-home study was conducted in CSID and healthy adults to evaluate the diagnostic utility of self-reported GI symptoms following administration of a sucrose challenge.
Methods: This study investigated the optimum symptom scoring with a sucrose challenge symptoms test (SCST) for diagnosing CSID in 45 confirmed patients and 118 healthy controls.
Adult-Onset Autoimmune Enteropathy Mimicking Disaccharidase Deficiency.
Gastroenterology Res
August 2024
Department of Pathology, Kaiser Permanente Sacramento Medical Center, CA 95825, USA.
Article Synopsis
- - Adult-onset autoimmune enteropathy is a rare condition causing severe diarrhea, weight loss, and malnutrition due to immune system damage to the intestines, often initially misdiagnosed as disaccharidase deficiency.
- - A case study reveals that despite initial tests showing low enzyme activity leading to a diagnosis of disaccharidase deficiency, further biopsy results showed significant intestinal damage indicating autoimmune enteropathy.
- - The study stresses the importance of comprehensive testing, including tissue biopsies, in diagnosing gastrointestinal disorders in adults and highlights the need for greater awareness of conditions like autoimmune enteropathy for better patient care.
Disaccharidase deficiencies and gastrointestinal symptoms in patients referred to gastroscopic examination: a single center study from Norway.
Scand J Gastroenterol
October 2024
Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
Article Synopsis
- The study examined the relationship between low disaccharidase enzyme activity and gastrointestinal symptoms, particularly in patients with irritable bowel syndrome (IBS).
- Out of 40 patients, 60% had disaccharidase deficiency, and half of those met the criteria for IBS, but most reported severe gastrointestinal symptoms regardless of enzyme levels.
- The results indicated no significant correlation between the level of disaccharidase deficiency and the severity of symptoms or the diagnosis of IBS.
Performance of empirical and model-based classifiers for detecting sucrase-isomaltase inhibition using theC-sucrose breath test.
J Breath Res
September 2024
Department of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, United States of America.
TheC-sucrose breath test (C-SBT) has been proposed to estimate sucrase-isomaltase (SIM) activity and is a promising test for SIM deficiency, which can cause gastrointestinal symptoms, and for intestinal mucosal damage caused by gut dysfunction or chemotherapy. We previously showed how various summary measures of theC-SBT breath curve reflect SIM inhibition. However, it is uncertain how the performance of these classifiers is affected by test duration.
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