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Photodynamic Effect of Amphiphilic NCN-Coordinated Platinum(II) Complexes in Human Umbilical Vein Endothelial Cells.
Inorg Chem
July 2024
Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
Here, we report a photodynamic therapy (PDT) photosensitizer of NCN-coordinated Pt(II) complexes: [Pt(L)(solv)] (HL = 1,3-(2-dipyridyl)benzene) and [Pt(L)]@HSA, which is the Pt(II) complex encapsulated in human serum albumin (HSA). The quantum yield of singlet oxygen production for [Pt(L)(solv)] is more than 50%, while that for [Pt(L)]@HSA is much lower. Photoimages of human umbilical vein endothelial cells (HUVECs) treated with the Pt(II) complexes suggest that [Pt(L)(solv)] is delocalized in the entire cell after the fast uptake by diffusion and [Pt(L)]@HSA is taken up by endocytosis and localized on organelles and the cell membrane.
View Article and Find Full Text PDFL-serine restored lysosomal failure in cells derived from patients with BPAN reducing iron accumulation with eliminating lipofuscin.
Free Radic Biol Med
August 2024
Neural Circuit Research Group, Korea Brain Research Institute, Daegu, South Korea. Electronic address:
Article Synopsis
- * Treatment with the iron chelator 2,2'-bipyridine (BIP) slightly reduced iron levels in the cytoplasm and mitochondria, but did not significantly improve lysosomal iron accumulation or levels of reactive oxygen species (ROS) related to oxidative stress in BPAN patient cells.
- * In contrast, l-serine treatment effectively reduced enlarged lysosomes, lowered iron accumulation, improved lysosomal activity by decreasing oxidized lipid levels, and diminished the
[High performance liquid chromatography combined with the 2,2'-dithiodipyridine derivatization reaction for determination of different types of free thiols in human serum and analysis of their relationship with coronary heart disease].
Se Pu
April 2024
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China.
Oxidative stress, which is characterized by an imbalance between antioxidants and free radicals, plays a pivotal role in the pathogenesis of coronary heart disease, a common and serious cardiovascular condition, and contributes significantly to its development and progression. Serum free thiols are crucial components of the body's antioxidant defense system. The accurate determination of serum free thiol levels provides a reference basis for understanding the body's status and monitoring the risk factors associated with the occurrence and progression of coronary heart disease.
View Article and Find Full Text PDFRational design of cuprofullerene bipyridine nanozyme with high peroxidase-like activity for colorimetric sensing of bleomycin.
Anal Bioanal Chem
November 2024
State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, 541004, People's Republic of China.
The high catalytic activity of Cu-based nanozymes mainly depends on the efficient Fenton-like reaction of Cu/ HO, but Cu cannot exist stably. Trying to find a material that can stably support Cu while promoting the electron cycle of Cu/Cu still faces serious challenges. C is expected to be an ideal candidate to solve this problem due to its unique structure and rich physicochemical properties.
View Article and Find Full Text PDFNucleobase-Functionalized 7-Deazaisoguanine and 7-Deazapurin-2,6-diamine Nucleosides: Halogenation, Cross-Coupling, and Cycloaddition.
J Org Chem
February 2024
Laboratory of Bioorganic Chemistry and Chemical Biology, Center for Nanotechnology, Heisenbergstrasse 11, 48149 Münster, Germany.
The functionalization in position-7 of 7-deazaisoguanine and 7-deazapurin-2,6-diamine ribo- and 2'-deoxyribonucleosides by halogen atoms (chloro, bromo, iodo), and clickable alkynyl and vinyl side chains for copper-catalyzed and copper-free cycloadditions is described. Problems arising during the synthesis of the 7-iodinated isoguanine ribo- and 2'-deoxyribonucleosides were solved by the action of acetone. The impact of side chains and halogen atoms on the p values and hydrophobicity of nucleosides was investigated.
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