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Engineered heart muscle allografts for heart repair in primates and humans.
Nature
January 2025
German Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Cardiomyocytes can be implanted to remuscularize the failing heart. Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We investigated the hypothesis that epicardial engineered heart muscle (EHM) allografts from induced pluripotent stem cell-derived cardiomyocytes and stromal cells structurally and functionally remuscularize the chronically failing heart without limiting side effects in rhesus macaques.
View Article and Find Full Text PDFOptical properties of InGaN/GaN red quantum well(QW) and their microcavities were studied and compared under optical pumping. Incidence of the excitation laser from the p-side was employed for both structures in order to acquire better emission characteristics. The QW structure was grown on sapphire substrate by metalorganic vapor-phase epitaxy(MOVPE) with a blue pre-layer QW.
View Article and Find Full Text PDFDilated SE-DenseNet for brain tumor MRI classification.
Sci Rep
January 2025
Department of Applied Mathematics, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
In the field of medical imaging, particularly MRI-based brain tumor classification, we propose an advanced convolutional neural network (CNN) leveraging the DenseNet-121 architecture, enhanced with dilated convolutional layers and Squeeze-and-Excitation (SE) networks' attention mechanisms. This novel approach aims to improve upon state-of-the-art methods of tumor identification. Our model, trained and evaluated on a comprehensive Kaggle brain tumor dataset, demonstrated superior performance over established convolution-based and transformer-based models: ResNet-101, VGG-19, original DenseNet-121, MobileNet-V2, ViT-L/16, and Swin-B across key metrics: F1-score, accuracy, precision, and recall.
View Article and Find Full Text PDFCore-Excited States for Open-Shell Systems in Similarity-Transformed Equation-of-Motion Theory.
J Chem Theory Comput
January 2025
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
X-ray absorption spectroscopy (XAS) is a powerful method for exploring molecular electronic structure by exciting core electrons into higher unoccupied molecular orbitals. In this study, we present the first integration of the spin-unrestricted similarity-transformed equation-of-motion coupled cluster method (CVS-USTEOM-CCSD) for core-excited and core-ionized states into the ORCA quantum chemistry package. Using the core-valence separation (CVS) approach, we evaluate the accuracy of CVS-USTEOM-CCSD across 13 open-shell organic systems, covering over 20 core excitations with diverse spin multiplicities (doublet, triplet, and quartet).
View Article and Find Full Text PDFStacked Scintillators Based Multispectral X-Ray Imaging Featuring Quantum-Cutting Perovskite Scintillators With 570 nm Absorption-Emission Shift.
Adv Mater
January 2025
State Key Laboratory of Extreme Photonics and Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Traditional energy-integration X-ray imaging systems rely on total X-ray intensity for image contrast, ignoring energy-specific information. Recently developed multilayer stacked scintillators have enabled multispectral, large-area flat-panel X-ray imaging (FPXI), enhancing material discrimination capabilities. However, increased layering can lead to mutual excitation, which may affect the accurate discrimination of X-ray energy.
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