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Article Synopsis
- - Large Granular Lymphocytic (LGL) leukemia is a rare type of cancer that often occurs alongside Rheumatoid Arthritis (RA) and is characterized primarily by low neutrophil counts.
- - Patients may show symptoms like spleen enlargement, resembling Felty's Syndrome, and while T-LGL leukemia is usually slow-growing, improper treatment can lead to serious health issues, primarily due to frequent infections.
- - The text discusses two cases highlighting the potential of Rituximab as an effective treatment for patients suffering from both T-LGL leukemia and RA.
The peculiar features, diversity and impact of citrulline-reactive autoantibodies.
Nat Rev Rheumatol
July 2024
Department of Medicine, Division of Rheumatology, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Since entering the stage 25 years ago as a highly specific serological biomarker for rheumatoid arthritis, anti-citrullinated protein antibodies (ACPAs) have been a topic of extensive research. This hallmark B cell response arises years before disease onset, displays interpatient autoantigen variability, and is associated with poor clinical outcomes. Technological and scientific advances have revealed broad clonal diversity and intriguing features including high levels of somatic hypermutation, variable-domain N-linked glycosylation, hapten-like peptide interactions, and clone-specific multireactivity to citrullinated, carbamylated and acetylated epitopes.
View Article and Find Full Text PDFThe impacts of obesity in rheumatoid arthritis and insights into therapeutic purinergic modulation.
Int Immunopharmacol
July 2024
Graduate Program in Medical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil. Electronic address:
Rheumatoid Arthritis (RA) is an autoimmune condition responsible for the impairment of synovia and joints, endangering the functionality of individuals and contributing to mortality. Currently, obesity is increasing worldwide, and recent studies have suggested an association between such condition and RA. In this sense, obese individuals present a lower capacity for achieving remission and present more intense symptoms of the disease, demonstrating a link between both disorders.
View Article and Find Full Text PDFRetinal microvascular alterations in patients with active rheumatoid arthritis without cardiovascular risk factors: the potential effects of T cell co-stimulation blockade.
Front Med (Lausanne)
February 2024
Rheumatology and Clinical immunology Unit, ASST Spedali Civili, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Background: The evaluation of microvascular alterations might provide clinically useful information for patients with an increased cardiovascular (CV) risk, such as those with rheumatoid arthritis (RA), being the small artery remodeling the earliest form of target organ damage in primary CV diseases, such as arterial hypertension. The evaluation of retinal arterioles is a non-invasive technique aimed to identify an early microvascular damage, represented by the increase of the wall-to-lumen ratio (WLR) index. Abatacept (ABA), a T-cell co-stimulator blocker, is used to treat RA.
View Article and Find Full Text PDFAutoantibody-negative rheumatoid arthritis: still a challenge for the rheumatologist.
Lancet Rheumatol
December 2023
Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Article Synopsis
- Researchers have learned a lot about a type of rheumatoid arthritis that has autoantibodies, leading to better treatment and recovery for patients.
- However, rheumatoid arthritis without these autoantibodies is still not well understood and might need different types of treatment.
- The goal of this review is to explain how autoantibody-negative rheumatoid arthritis is different and to encourage more research on this tricky condition.
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